Synchronized Dual Channel Pump for CSF Membrane Dialysis
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Solution Overview
Problem
Current treatments for neuroinflammatory diseases and disorders, such as Alzheimer's and Parkinson's, are inadequate in reducing lower molecular weight immune mediators in cerebrospinal fluid, which exacerbate these conditions.
Innovation Solution
A method involving a synchronized dual channel pump to draw cerebrospinal fluid from the subarachnoid space, subject it to membrane dialysis to reduce immune or inflammatory mediators, and return the dialyzed fluid, optionally removing cellular matter through centrifugation, magnetic or electrical fields, or charged filters, to minimize inflammatory components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If membrane dialysis is applied to CSF to reduce immune mediators, then therapeutic effectiveness is improved, but device complexity increases
Solution Approach 1:
The pump system is divided into two synchronized channels: one for drawing CSF and one for returning dialyzed CSF. This segmentation allows independent optimization of each channel's function while maintaining overall system coordination, resolving the contradiction between therapeutic effectiveness and device complexity
Solution Approach 2:
The dialysis device integrates multiple functions into a single system: CSF withdrawal, cellular matter removal, membrane dialysis for immune mediator reduction, and return of treated CSF. This multi-functionality improves therapeutic effectiveness while avoiding the need for multiple separate devices that would increase overall complexity
2Manufacturing precision
If cellular matter is removed from CSF through multiple methods, then purity of dialysate is improved, but device complexity increases
Solution Approach 1:
Cellular matter is removed from CSF before the dialysis process begins. This preliminary action ensures that cells do not interfere with the membrane dialysis process or contaminate the dialysate, achieving high purity without requiring complex integrated cell removal mechanisms within the dialysis unit itself
Solution Approach 2:
The patent introduces an intermediary processing step between CSF withdrawal and dialysis. This intermediary stage handles cellular matter removal through various methods, acting as a buffer that protects the dialysis system from cell contamination while maintaining operational simplicity
3Reliability
If synchronized dual channel pump is used for CSF withdrawal and return, then treatment reliability is improved, but device complexity increases
Solution Approach 1:
The pump system employs dynamic synchronization between two channels, allowing real-time coordination of withdrawal and return flows. This dynamic control ensures that CSF is continuously circulated through dialysis while maintaining stable intracranial pressure, improving treatment reliability without requiring overly complex control mechanisms
Solution Approach 2:
The patent combines CSF withdrawal and return functions into a single integrated pump system with two channels. This merging approach ensures coordinated operation and consistent flow rates while avoiding the need for completely separate pump systems, thereby improving reliability without proportionally increasing device complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach effectively reduces inflammatory mediators in cerebrospinal fluid, thereby ameliorating neuroinflammatory disorders, including cerebral hemorrhage, acute brain injury, encephalitis, meningitis, Alzheimer's, and Parkinson's disease by minimizing pathological inflammatory pathways.
Implementation Method 1
subjecting the drawn CSF to membrane dialysis against a dialysate fluid to reduce immune or inflammatory mediators
Implementation Method 2
reduces cellular material by: flow centrifugation effective to reduce cell content
Implementation Method 3
subjecting a flow pathway for the CSF to magnetic or electrical fields that cause cells to bias towards flowing through one or more side channels
Implementation Method 4
subjecting a flow pathway for the CSF to magnetic or electrical fields that cause cells to bias towards flowing through one or more side channels
Implementation Method 5
flowing the CSF through a charged filter effective to retain human or other vertebrate cells
Data Source
AI summary
Provided, among other things, is a method of treating cerebral spinal fluid comprising: (a) utilizing a channel of a pump to draw CSF from a subject's subarachnoid space of the subject's brain or spinal column; (b) subjecting the drawn CSF to membrane dialysis against a dialysate fluid to reduce immune or inflammatory mediators; and (c) utilizing a second channel of the synchronized dual channel pump to return the dialyzed CSF to the subarachnoid space of the subject's brain or spinal column. For example, the pump can be a synchronized dual channel pump. In one embodiment, the method further comprises: (d) removing cellular matter from the CSF to produce reduced cell content CSF, wherein the reduced cell content CSF is subjected to membrane dialysis.