CT Number Correction for Small Vessel Plaque Quantification

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Solution Overview

Problem

Current computed tomography (CT) technology struggles to accurately measure and characterize small vessel plaque in coronary arteries due to limitations in spatial resolution, leading to inadequate detection and characterization of high-risk coronary plaque, which is crucial for risk stratification and atherosclerosis assessment.

Innovation Solution

A novel mathematical correction function is developed to correct CT numbers based on the geometric size of the target object, using a formula that accounts for the reduction in CT number with object size, allowing for accurate characterization of both calcified and non-calcified plaque, independent of detector row configuration, contrast medium density, and reconstruction filter kernels.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If matrix reconstruction algorithms are used in current CT units, then the diagnostic capability for visualizing contrast enhanced lumen is improved, but the CT number and contrast are reduced for smaller objects like vessels and intimal plaque

Engineering Contradiction:
Improvediagnostic capabilityVSAvoidCT number accuracy
Core Design Contradiction:
ReliabilityVSMeasurement precision

Solution Approach 1:

The patent applies parameter changes by introducing a size-dependent correction function that adjusts CT numbers based on the geometric size of the target object. The correction function modifies the measured CT number using the formula: Corrected CT number = Measured CT number / (1 - correction factor), where the correction factor is derived from the object's size. This parameter adjustment compensates for the size-related attenuation artifacts introduced by matrix reconstruction algorithms, thereby recovering accurate CT numbers for small vessels and plaque while preserving the diagnostic capability enhanced by these algorithms.

Inventive Principle:
Principle #35Parameter changes

2Measurement precision

If CT technology is improved with more detector rows and faster gantry rotation, then temporal and contrast resolution are improved, but spatial resolution is not improved

Engineering Contradiction:
Improvecontrast resolutionVSAvoidspatial resolution
Core Design Contradiction:
Measurement precisionVSManufacturing precision

Solution Approach 1:

The patent replaces mechanical/improvement-based spatial resolution enhancement with a computational correction approach. Instead of relying on physical improvements in detector geometry or reconstruction algorithms to achieve better spatial resolution, the system uses a mathematical correction function that compensates for size-related measurement errors. This substitution allows the system to maintain accurate measurements of small objects (vessels and plaque) without requiring physical improvements in spatial resolution capabilities.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Measurement precision

If the correction function is applied to compensate for size-related CT number reduction, then measurement precision for small objects is improved, but device complexity increases

Engineering Contradiction:
ImproveCT number accuracy for small objectsVSAvoidcorrection system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent applies the copying principle by creating a simplified mathematical model (correction function) that replicates and compensates for the size-related measurement errors. The correction function uses a straightforward formula based on the object's geometric size, avoiding the need for complex iterative reconstruction algorithms or additional hardware. By copying the error pattern and applying its inverse, the system achieves improved measurement precision for small objects with minimal increase in computational complexity.

Inventive Principle:
Principle #26Copying

Data Source

PatentUS8818058B2Method for determining a correction function for correcting computed tomographic numbers of a small target object in a CT image
Publication Date: 2014.08.26 TOSHIBA MEDICAL SYST CORP
  • US8818058B2 patent drawing
  • US8818058B2 patent drawing
  • US8818058B2 patent drawing

AI summary

A method of correcting target region in computed tomographic (CT) image, including the steps of obtaining a CT image of a patient; determining the size of a target object in the CT image; and correcting CT numbers of a portion of the CT image that corresponds to the target object, based on the determined size of the target object.