Cuff Device Multi-Parameter Hemodynamic Monitoring
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Solution Overview
Problem
Current hemodynamic monitoring devices in surgical and intensive care settings lack non-invasive and automated methods for simultaneously measuring blood pressure (BP), cardiac output (CO), and left ventricular ejection fraction (EF), which are crucial for managing hypotension and guiding therapy, especially in patients with conditions like septic shock or COVID-19-induced acute respiratory distress syndrome.
Innovation Solution
A method and system using a non-invasive cuff device to measure cuff pressure waveforms during inflation and deflation, compute systolic and diastolic blood pressure, construct a blood pressure waveform, and calculate cardiac output and left ventricular ejection fraction, incorporating additional patient information such as age, height, and weight, and employing machine learning and physiologic modeling to improve accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If pulse contour and volume-clamp devices are used for hemodynamic monitoring, then non-invasive measurement is achieved, but the devices cannot measure left ventricular ejection fraction and require special servo-controlled finger cuffs with optical sensors
Solution Approach 1:
The patent applies multi-functionality by integrating BP, CO, and EF measurement capabilities into a single cuff device. The system uses a unified pressure sensor and processing unit that can derive multiple hemodynamic parameters from the same input signal, eliminating the need for separate specialized devices for each measurement.
Solution Approach 2:
The patent replaces complex mechanical systems (optical sensors, servo-controlled finger cuffs) with a simpler pressure-based measurement system. By using standard pressure sensors and computational algorithms, the system achieves non-invasive measurement of multiple parameters without requiring specialized mechanical components.
2Ease of operation
If volume-clamp devices with finger BP waveform measurement are used, then non-invasive monitoring is achieved, but the devices become ineffective during finger hypo-perfusion episodes
Solution Approach 1:
The patent introduces an intermediary approach by using brachial artery pressure measurement as a proxy for central hemodynamic status. The brachial artery, being larger and less susceptible to perfusion changes, provides a more reliable signal that can infer central BP, CO, and EF even when peripheral finger perfusion is compromised.
3Measurement precision
If pulmonary artery catheter devices are used to measure CO and right ventricular ejection fraction, then accurate measurement is achieved, but the devices are highly invasive
Solution Approach 1:
The patent replaces invasive mechanical measurement systems (pulmonary artery catheters with thermodilution) with non-invasive pressure-based measurement and computational modeling. By using cuff pressure waveforms and algorithms that simulate hemodynamic calculations, the system achieves similar measurement capabilities without penetrating the body.
4Measurement precision
If Doppler ultrasound and echocardiography devices are used to measure CO and EF, then accurate imaging is achieved, but the devices require trained operators to steadily direct probes or frequently reposition probes
Solution Approach 1:
The patent implements self-service by using automated pressure waveform analysis that requires no operator intervention. The system automatically captures pressure signals, processes the waveforms through computational algorithms, and derives hemodynamic parameters without requiring skilled operators to manually position or adjust probes during measurement.
5Ease of operation
If impedance cardiography devices are used for non-invasive CO measurement, then CO can be measured without invasive catheters, but the devices are inaccurate due to interference from lung fluids
Solution Approach 1:
The patent uses brachial artery pressure measurement as an intermediary that is not affected by lung fluid interference. By measuring pressure in the arm (distal to the lung field) and using waveform analysis to infer central hemodynamics, the system avoids the confounding effect of thoracic fluid on electrical impedance measurements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables simultaneous, accurate, and non-invasive monitoring of BP, CO, and EF, reducing mortality and morbidity by providing real-time, patient-specific data for fluid therapy management and improving clinical outcomes.
Implementation Method 1
measuring a cuff pressure waveform of a subject during inflation and/or deflation of the cuff device
Data Source
AI summary
Devices and methods for multi-parameter hemodynamic monitoring are provided. Determining a cardiac output of a patient using a cuff device includes measuring a cuff pressure waveform of a subject during inflation and/or deflation of the cuff device, computing systolic and diastolic blood pressure from the cuff pressure waveform using the cuff device, constructing a blood pressure waveform from the systolic and diastolic blood pressure and cuff pressure waveform using the cuff device, computing brachial artery compliance from the cuff pressure waveform, and computing the cardiac output from the blood pressure waveform and/or brachial artery compliance using the cuff device.