CuInS2@ZnS Nanomaterial Flash Chemiluminescence System

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Solution Overview

Problem

Current chemiluminescence (CL) liquid compositions using CuInS2/ZnS nanomaterials with hydrazine hydrate as a triggering reagent suffer from low intensity and long CL times, making them unsuitable for rapid analysis, while traditional flash-type CL substances like acridinium ester have complex synthesis steps and are photounstable.

Innovation Solution

A flash-type CL liquid composition utilizing CuInS2/ZnS nanomaterials excited by Tris-N2H4.H2O—H2O2, which simplifies synthesis, enhances CL intensity, and provides photostability, with CL times ranging from 1-10 seconds and emission in the near-infrared region.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Illumination intensity

If CuInS2/ZnS nanomaterial with hydrazine hydrate is used as chemiluminescence liquid composition, then the composition can generate CL radiation in near-infrared region, but the CL intensity is low and CL time is long

Engineering Contradiction:

ImproveCL intensityVSAvoidCL time

Core Design Contradiction:

Illumination intensityVSDuration of action of moving object

Solution Approach 1:

The patent changes the chemical parameters of the triggering reagent by replacing pure hydrazine hydrate with a Tris buffer solution containing N2H4.H2O and H2O2. This parameter change transforms the CL characteristics from low intensity and long duration to high intensity and short duration (1-10 seconds), achieving flash-type chemiluminescence while maintaining near-infrared emission

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite triggering system by combining Tris buffer, hydrazine hydrate, and hydrogen peroxide. This composite reagent system synergistically enhances the CL intensity and shortens the CL duration, resolving the contradiction between intensity and time duration

Inventive Principle:

Principle #40Composite materials

2Duration of action of moving object

If acridinium ester is used as flash-type CL substance, then high CL intensity and short CL time are achieved, but synthesis steps are complicated and products are easy to decompose under light

Engineering Contradiction:

ImproveCL timeVSAvoidsynthesis complexity

Core Design Contradiction:

Duration of action of moving objectVSEase of manufacture

Solution Approach 1:

The patent replaces the complex-to-synthesize acridinium ester with CuInS2/ZnS nanomaterials that can be prepared via simple one-pot hydrothermal methods. Although the nanomaterials are designed for short-duration flash CL, their ease of synthesis and stability under storage conditions make them superior to acridinium ester for practical applications

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent substitutes the organic acridinium ester molecule with an inorganic nanomaterial system (CuInS2/ZnS). This substitution replaces complex organic synthesis with simpler inorganic material preparation, while also improving photostability and maintaining flash-type CL characteristics

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Illumination intensity

If acridinium ester is used as flash-type CL substance, then high CL intensity is achieved, but products are easy to decompose under light

Engineering Contradiction:

ImproveCL intensityVSAvoidphotostability

Core Design Contradiction:

Illumination intensityVSStability of the object's composition

Solution Approach 1:

The patent replaces photounstable acridinium ester with photostable CuInS2/ZnS nanomaterials. The inorganic nanomaterial core provides inherent photostability while the surface ligands enable controlled flash-type CL emission with high intensity, simultaneously resolving both intensity and stability requirements

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The CuInS2/ZnS nanomaterial-based CL liquid composition achieves high-intensity, short-duration CL signals, overcoming the limitations of previous compositions and offering improved photostability and ease of synthesis, suitable for rapid biological detection.

Implementation Method 1

a CuInS2/ZnS nanomaterial as a chemiluminescent substance and a Tris buffer solution containing N2H4.H2O and H2O2 as an triggering solution form the flash-type CL liquid composition

Methodology Applied

Scientific EffectChemiluminescence: Chemiluminescence

Data Source

PatentUS20230067974A1Flash-type chemiluminescence system based on cuins2@zns nanomaterial

Publication Date: 2023.03.02 SHANDONG UNIV

AI summary

A CuInS2@ZnS nanomaterial synthesized with thiosalicylic acid and sodium citrate as dual-stabilizers is taken as a chemiluminescent luminophore, and Tris buffer containing both N2H4.H2O and H2O2 is taken as the triggering solution; introducing the H2O2 into the triggering solution can bring out greatly enhanced CL emission and obviously shortened CL process, enable the CuInS2@ZnS nanomaterial with strong flash-type and near-infrared CL; the luminophore of CuInS2@ZnS nanomaterial is synthesized by a one-pot method; compared with acridinium ester (a classical flash-type chemiluminescent substance), the CuInS2@ZnS nanomaterial is simple in synthesis method, mild in conditions and short in the required time, the synthesized CuInS2@ZnS nanomaterial is not easy to decompose under light, and the CL waveband is in the near-infrared region.