Curable Composition Adhesion Biocompatibility Trade-off

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Solution Overview

Problem

Current curable compositions for artificial organs and medical instruments face a trade-off between substrate adhesion and biocompatibility, where achieving excellent adhesion to biological fluids often results in poor compatibility with biological materials, and vice versa.

Innovation Solution

A curable composition containing specific polyfunctional compounds with acrylamide and acrylate groups, combined with a betaine monomer, which enhances both substrate adhesion and biocompatibility by improving hydrophilicity and hydrophobicity properties, ensuring the cured product remains adhered to substrates even in aqueous environments.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If a curable composition is designed to achieve excellent substrate adhesion, then the film adheres well to substrates, but biological materials tend to adhere to the film surface

Engineering Contradiction:

Improvesubstrate adhesionVSAvoidbiological material adhesion

Core Design Contradiction:

StrengthVSObject-affected harmful factors

Solution Approach 1:

The patent applies local quality by incorporating both hydrophilic groups (acrylamide, carboxyl) and hydrophobic groups (acrylate, methyl) within the same polymer structure. This creates different surface regions with different wetting properties - the hydrophilic regions interact with aqueous body fluids while the hydrophobic regions resist biological material adhesion, allowing simultaneous achievement of substrate adhesion and biocompatibility

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent uses composite materials by combining multiple functional monomers (acrylamide-based, carboxyl-based, and acrylate-based) in a single curable composition. This composite approach allows the polymer network to exhibit both strong substrate adhesion through hydrophilic interactions and resistance to biological material adhesion through hydrophobic effects, resolving the trade-off between these two properties

Inventive Principle:

Principle #40Composite materials

2Object-affected harmful factors

If a curable composition is designed to achieve excellent biocompatibility, then biological materials are inhibited from adhering, but substrate adhesion becomes poor

Engineering Contradiction:

Improvebiological material adhesionVSAvoidsubstrate adhesion

Core Design Contradiction:

Object-affected harmful factorsVSStrength

Solution Approach 1:

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent uses parameter changes by carefully controlling the ratio and composition of different monomers (acrylamide-based, carboxyl-based, and acrylate-based) to optimize the balance between hydrophilic and hydrophobic characteristics. By adjusting these compositional parameters, the patent achieves both excellent substrate adhesion and biocompatibility in the cured product

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition achieves excellent substrate adhesion and biocompatibility, preventing peeling from hydrophobic substrs immersed in water and inhibiting biological material adhesion, making it suitable for long-term medical applications like prostheses and dental materials.

Implementation Method 1

a curable composition containing a specific polyfunctional compound and a specific polyfunctional (meth)acrylamide compound or a betaine monomer

Methodology Applied

Scientific EffectPhotopolymerization: Photopolymerisation

Data Source

PatentEP3699209B1Curable composition, film, cured product, and medical member

Publication Date: 2021.10.27 FUJIFILM CORP

AI summary

Provided is a curable composition capable of providing a cured product excellent in both the substrate adhesion and biocompatibility. Also provided are a cured product and a film, which are excellent in both the substrate adhesion and biocompatibility, and a medical member which includes the cured product. The curable composition contains a predetermined compound containing a substituted or unsubstituted acrylamide group and a substituted or unsubstituted acrylate group, and a predetermined compound containing a (meth)acrylamide group or a betaine monomer.