Curable Composition for Medical Substrates
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Solution Overview
Problem
Current curable compositions used for artificial organs and medical instruments do not adequately meet the requirements for both substrate adhesion and biocompatibility, particularly when exposed to aqueous environments, leading to potential peeling issues and biological material adhesion.
Innovation Solution
A curable composition incorporating betaine monomers and polyfunctional (meth)acrylamide compounds, which form high crosslinking density films that inhibit aqueous liquid permeation and exhibit excellent biocompatibility, ensuring strong substrate adhesion and reduced biological material adhesion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If a curable composition containing sulfobetaine monomer and crosslinking agent is used to achieve biocompatibility, then biological material adhesion is reduced, but substrate adhesion deteriorates
Solution Approach 1:
The invention changes the chemical structure parameters of the monomer by introducing specific groups (carboxyl, hydroxyl, or amine groups) into the betaine monomer structure. This structural modification enables the material to simultaneously achieve nonadhesion to biological materials and strong adhesion to substrates like glass and metal, resolving the contradiction between biocompatibility and substrate adhesion.
Solution Approach 2:
The invention creates a composite curable composition by combining specifically modified betaine monomers with crosslinking agents. This composite approach allows the cured product to exhibit both excellent substrate adhesion and resistance to biological material adhesion, achieving properties that neither component alone could provide.
2Reliability
If film is immersed in aqueous liquid to test adhesion, then peeling resistance is evaluated, but water permeation causes adhesion failure
Solution Approach 1:
The invention modifies the chemical composition parameters of the curable system by incorporating monomers with specific functional groups that create a dual-function cured film. The film structure is designed to be impermeable to water while maintaining strong interfacial adhesion, allowing the film to resist peeling even when immersed in aqueous liquids for extended periods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves excellent substrate adhesion and biocompatibility, preventing peeling from aqueous environments and minimizing biological material attachment, making it suitable for long-term medical applications such as prostheses and medical instruments.
Implementation Method 1
a curable composition containing one or more betaine monomers selected from the group consisting of a compound represented by Formula (1) and a compound represented by Formula (2), and one or more polyfunctional compounds selected from the group consisting of a compound represented by Formula (A1) and a compound represented by Formula (A2)
Data Source
AI summary
A curable composition contains a betaine monomer having a predetermined structure and a polyfunctional (meth)acrylamide compound having a predetermined structure.