Curcin Nematicidal Seed Coating for Season-Long Nematode Control

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Solution Overview

Problem

Existing nematicides used to combat nematodes in agriculture have undesirable side effects, including high toxicity and environmental impact, leading to restrictions on their use and a need for a safer, sustainable alternative.

Innovation Solution

The use of isolated and purified curcin or curcin-like proteins derived from Jatropha curcas, either naturally or through recombinant technology, as a nematicidal ingredient in a composition.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If nematodes are controlled by existing methods, then nematode populations are reduced, but the methods are not cost-effective and do not provide season-long control

Engineering Contradiction:
Improveseason-long controlVSAvoidcost-effectiveness
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The patent applies preliminary action by incorporating the nematicidal composition into the seed coating process before planting. This allows the protective effect to be established in advance, providing season-long control as the seedling grows and the active ingredients are released over time, eliminating the need for multiple costly applications throughout the growing season.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The composition is designed to be applied once during seed treatment and then provides self-sustaining protection throughout the plant's growth cycle. The controlled release mechanism allows the active ingredients to serve themselves by continuously protecting the plant from nematodes without requiring additional human intervention or application costs.

Inventive Principle:
Principle #25Self-service

2Reliability

If nematodes are controlled by existing methods, then some protection is provided, but the methods do not provide season-long control

Engineering Contradiction:
Improveseason-long controlVSAvoidapplication frequency
Core Design Contradiction:
ReliabilityVSQuantity of substance

Solution Approach 1:

The patent achieves continuity of useful action through the controlled release formulation in the seed coating. The active ingredients are released continuously over the entire growing season, maintaining effective concentrations against nematodes throughout plant development. This single continuous protective action replaces multiple discrete applications that would otherwise be needed.

Inventive Principle:
Principle #20Continuity of useful action

Solution Approach 2:

The composition employs dynamic release characteristics where the active ingredients are gradually released from the seed coating as the seed germinates and the plant grows. This dynamic delivery system adapts to the plant's developmental stages, providing protection when and where it is most needed throughout the season without requiring reapplication.

Inventive Principle:
Principle #15Dynamics

3Reliability

If a broad spectrum of microbes is used to promote plant growth, then plant health is improved, but harmful organisms such as nematodes may also be promoted

Engineering Contradiction:
Improveplant healthVSAvoidnematode promotion
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies local quality by creating distinct functional zones in the seed coating: one zone containing nematicidal active ingredients to protect against harmful nematodes, and another zone containing beneficial microbes to promote plant growth. Each component is localized to perform its specific function without interfering with the other, allowing simultaneous protection and growth promotion.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The seed coating formulation acts as an intermediary that mediates between beneficial microbes and harmful nematodes. The physical structure and chemical composition of the coating create a protective barrier that allows beneficial microbes to colonize and benefit the plant while blocking or killing nematodes before they can reach and harm the seedling.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Curcin or curcin-like proteins effectively control nematodes with reduced toxicity and environmental impact, demonstrating significant nematicidal activity even at low concentrations, while maintaining soil health.

Implementation Method 1

effective against a broad spectrum of plant-parasitic nematodes including but not limited to Root-knot nematodes (Meloidogyne spp.), Corky root nematodes (Acrobeloides sp.), Reniform nematodes (Rotylenchulus reniformis), Sting nematodes (Belonolaimus sp.), Spiral nematodes (Helicotylenchus sp.), Dagger nematodes (Xiphinema spp.), and Needle nematodes (Longidorus sp.)

Methodology Applied
Scientific EffectToxicity:

Implementation Method 2

The beneficial microbes may suppress harmful organisms through various mechanisms, including competition for resources, production of antibiotics, and induction of plant defense responses.

Methodology Applied
Scientific EffectBiological control:

Implementation Method 3

The composition provides season-long control through controlled release mechanisms that maintain effective concentrations of nematicidal agents throughout the growing season.

Methodology Applied
Scientific EffectControlled release:

Data Source

PatentEP4557954B1The control of nematodes
Publication Date: 2026.05.20 MAGRIX (PTY) LTD
  • EP4557954B1 patent drawingFigure 1~2
  • EP4557954B1 patent drawingFigure 3~4
  • EP4557954B1 patent drawingFigure 5~6

AI summary

A nematicidal composition includes curcin or a curcin-like protein as active nematicidal ingredient. The curcin or curcin-like protein is a protein which has at least 90% sequence identity with the amino acid sequence of SEQ ID NO: 1. A method of controlling nematodes is also provided.