Curcuminoid Composition with Ar-turmerone for Enhanced Bioavailability
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Solution Overview
Problem
Curcumin has low bioavailability due to poor absorption and rapid metabolism, limiting its effectiveness in human subjects despite its promising preclinical anti-inflammatory and cancer-preventive properties.
Innovation Solution
A composition of curcuminoid admixed with a suitable proportion of ar-turmerone, the main component of turmeric essential oil, significantly enhances the bioavailability of curcumin, with a weight ratio ranging from 1:1 to 99:1, resulting in a 2-fold to 16-fold increase in curcumin levels in the blood compared to curcuminoid alone.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If curcuminoid is administered alone, then the formulation is simple, but the bioavailability is low due to poor absorption and rapid metabolism
Solution Approach 1:
The patent combines curcuminoid with essential oil of turmeric to create a composite formulation. This composite approach leverages the synergistic interaction between curcuminoid and ar-turmerone, where the essential oil components enhance the absorption and stability of curcuminoid, thereby improving bioavailability without significantly complicating the formulation process.
2Ease of operation
If curcuminoid is administered alone, then the administration is simple, but the curcumin levels in blood are insufficient
Solution Approach 1:
The essential oil of turmeric acts as an intermediary substance that facilitates the absorption and utilization of curcuminoid. Ar-turmerone in the essential oil enhances the pharmacokinetic properties of curcuminoid, leading to significantly higher curcumin levels in blood while maintaining simple oral administration.
3Loss of energy
If curcuminoid is administered alone, then the metabolic burden is low, but the pharmacological effectiveness is limited
Solution Approach 1:
The patent changes the compositional parameters by adding essential oil of turmeric to the curcuminoid formulation. This parameter change results in altered pharmacokinetic parameters including enhanced absorption rate, increased bioavailability, and sustained curcumin levels in blood, thereby improving pharmacological effectiveness without substantially increasing metabolic burden.
Data Source
AI summary
A composition for enhanced bioavailability of curcumin including purified curcuminoid and purified essential oil of turmeric. A method to prepare a composition for enhanced bioavailability of curcumin having purified curcuminoid and purified essential oil of turmeric.