Curcumin Complex with Water-Soluble Cellulose Derivative
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Solution Overview
Problem
Current curcumin compositions for oral intake have insufficient absorbability and require complex or costly production methods, and existing complexes focused on photostability and coloring power do not adequately address absorption enhancement.
Innovation Solution
A complex formed from curcumin and/or its analogs with a water-soluble cellulose derivative, specifically methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose, or their salts, which enhances oral absorbability and can be produced through a simple solvent removal process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If curcumin is used alone, then the composition is simple and inexpensive, but the oral absorbability is low
Solution Approach 1:
The patent creates a composite material by combining curcumin with a water-soluble cellulose derivative. This composite structure allows curcumin to form inclusion complexes with the cellulose derivative, significantly improving oral absorbability while maintaining production simplicity through straightforward mixing and drying processes.
2Reliability
If curcumin is combined with gum ghatti, then the oral absorbability is enhanced, but the production process becomes complicated
Solution Approach 1:
The patent changes the type of carrier material from gum ghatti to water-soluble cellulose derivatives. This parameter change maintains the ability to enhance oral absorbability while simplifying the production process, as the cellulose derivatives can be more easily processed and do not require the complex operations needed for gum ghatti-based formulations.
3Stability of the object's composition
If curcumin is complexed with polysaccharides or proteins, then the photostability and coloring power are improved, but the oral absorbability enhancement is not addressed
Solution Approach 1:
The water-soluble cellulose derivative serves multiple functions simultaneously: it acts as a complexing agent to improve photostability, maintains coloring power, and crucially enhances oral absorbability. This multi-functional approach eliminates the need for separate formulations targeting different properties.
4Reliability
If existing curcumin compositions are used, then some absorbability enhancement is achieved, but special technologies or complicated operations are needed
Solution Approach 1:
The patent employs water-soluble cellulose derivatives that are inexpensive, readily available, and easy to process. These materials can be used in straightforward mixing and drying operations without requiring expensive special technologies, making the production process both cost-effective and simple while achieving superior absorbability enhancement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The complex significantly improves the oral absorbability of curcumin, allowing for effective physiological effects in pharmaceutical, cosmetic, and nutritional applications, offering a convenient and cost-effective solution.
Implementation Method 1
a complex formed from curcumin and/or an analog thereof and a water-soluble cellulose derivative
Data Source
AI summary
Provided is a composition for oral intake, which exhibits improved oral absorbability of curcumin and/or an analog thereof and can be produced conveniently and inexpensively. A complex of curcumin and/or an analog thereof and a water-soluble cellulose derivative is disclosed.