Curcumin Derivative for Personal Care with Reduced Color
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Solution Overview
Problem
Current anti-inflammatory agents, such as curcumin, face challenges in cosmetic compositions due to their strong yellow color, which affects visual appeal, and have limitations in solubility and melting point, making them less suitable for various personal care products.
Innovation Solution
A novel compound with the chemical structure of 1,3-bis(2-(4-hydroxy-3-methoxyphenyl)cyclopropyl)-2,2-dimethylpropane-1,3-dione is developed through a process involving protection of phenolic hydroxyl groups, di-methylation, di-cyclopropanation, and deprotection of curcumin, resulting in a derivative with reduced yellow color, improved solubility, and lower melting point.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If curcumin is used as an anti-inflammatory agent, then anti-inflammatory efficacy is achieved, but the strong yellow color negatively affects visual appeal
Solution Approach 1:
The patent applies parameter changes by chemically modifying curcumin to create derivatives with altered physical properties. Specifically, the curcumin structure is modified to produce compounds with reduced yellow color intensity while retaining the anti-inflammatory pharmacological activity, thus changing the optical parameters without sacrificing therapeutic efficacy
Solution Approach 2:
The invention creates composite chemical structures by combining curcumin core structure with additional functional groups or moieties. This results in hybrid molecules that exhibit both the desired anti-inflammatory properties of curcumin and improved color characteristics, effectively creating a composite material with superior overall performance
2Reliability
If curcumin is used in personal care products, then anti-inflammatory benefits are provided, but solubility limitations reduce suitability for various formulations
Solution Approach 1:
The patent modifies the chemical parameters of curcumin by introducing hydrophilic groups or altering the molecular structure to enhance water solubility. This allows the anti-inflammatory agent to be effectively incorporated into aqueous-based personal care formulations while maintaining its biological activity
Solution Approach 2:
The invention may employ solubility-enhancing intermediaries such as cyclodextrins, surfactants, or cosolvents that complex with or facilitate the dissolution of curcumin derivatives. These intermediary substances act as mediators between the hydrophobic curcumin structure and the aqueous formulation environment, enabling effective delivery
3Reliability
If curcumin is used in cosmetic compositions, then therapeutic effects are achieved, but high melting point limits formulation options
Solution Approach 1:
The patent applies parameter changes by chemically modifying curcumin to produce derivatives with lower melting points. This structural modification reduces the thermal energy required for phase transition, enabling the compound to be incorporated into formulations that require lower processing temperatures or have specific rheological requirements
Data Source
Figure 1~2
AI summary
J8776WO CPL 36 ABSTRACT The invention relates to a novel compound of the curcuminoid class and to a process of preparing it. It has been shown to have anti-inflammatory benefit and can be utilised in a wide range of personal care products, while not having the strong yellow colouration that is characteristic of many compounds of this class.