Curcumin-FDP Metal Salt Complex for Skin Regeneration
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Solution Overview
Problem
Current cosmetic and pharmaceutical compositions are ineffective in maintaining or restoring skin cells to their basal physiological state, leading to inadequate prevention of skin aging and wrinkle formation, and insufficient treatment of skin pathologies caused by external and internal factors.
Innovation Solution
A composition combining curcumin, fructose 1-6 diphosphate, and biologically acceptable metal or oxide salts, which form complexes to enhance their activity, along with excipients, to regenerate skin cells by preventing oxidative stress and inflammation, thereby preventing elastosis and promoting skin hydration and elasticity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cosmetic and pharmaceutical compositions are used, then skin protection and regeneration are attempted, but the effectiveness is insufficient to restore skin cells to their basal physiological state
Solution Approach 1:
The patent employs a composite formulation combining curcumin (an anti-inflammatory polyphenol), fructose 1-6 diphosphate (a glycolytic intermediate that enhances cellular energy metabolism), and metal salts or oxides (which may act as cofactors or stabilizers). This multi-component system works synergistically to address multiple aspects of skin cell dysfunction simultaneously, thereby achieving reliable restoration of basal physiological state with enhanced effectiveness compared to single-component conventional compositions.
Solution Approach 2:
The invention changes the chemical and metabolic parameters within skin cells by introducing fructose 1-6 diphosphate, which directly influences glycolytic pathway activity and cellular energy production. This parameter change in cellular metabolism enables skin cells to regain their basal physiological state more effectively, addressing the insufficiency of conventional compositions that do not actively modify cellular metabolic parameters.
2Object-affected harmful factors
If conventional compositions are used to prevent skin aging, then some protection is provided, but wrinkle formation and elastosis are not adequately prevented
Solution Approach 1:
The patent converts the harmful effects of oxidative stress and inflammation into beneficial outcomes by using curcumin, which possesses potent antioxidant and anti-inflammatory properties. Curcumin neutralizes reactive oxygen species and modulates inflammatory pathways, thereby converting the harmful oxidative environment into a protective state that prevents wrinkle formation and elastosis, achieving reliable prevention where conventional compositions fail.
Solution Approach 2:
Fructose 1-6 diphosphate acts as an intermediary substance that mediates cellular energy metabolism and stress response. It facilitates the conversion of glucose through glycolysis, providing energy substrates and metabolic intermediates that support cellular repair mechanisms and protect against oxidative damage, thereby enhancing the prevention of skin aging manifestations.
3Stability of the object's composition
If skin cells are exposed to external and internal damaging factors, then cellular distress occurs leading to loss of elasticity and wrinkles, but conventional compositions cannot effectively restore the basal physiological state
Solution Approach 1:
The patent applies preliminary protective action by using curcumin to preemptively neutralize oxidative stress and inflammatory responses before they can cause irreversible damage to skin cell physiology. The composition is designed to be applied proactively to maintain skin cell stability and prevent the progression from cellular distress to permanent structural changes such as wrinkle formation and loss of elasticity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively restores skin cells to their basal state, significantly increasing skin hydration and elasticity, and preventing oxidative damage, as demonstrated by clinical and cellular experiments, making it suitable for both cosmetic and dermatological use.
Implementation Method 1
curcumin, fructose 1-6 diphosphate, a metal or basic oxide, or a biologically acceptable salt thereof, or its labile coordination compound able to form, with at least one of said compounds: complexes, derivatives or associations which enhance their activity
Implementation Method 2
Fructose 1-6 diphosphate (abbreviated to FDP hereinafter) is particularly preferred. The stated phosphosaccharides, and in particular FDP, are metabolites of glycolysis able to provide easily available energy for cell biochemistry
Implementation Method 3
compositions in the form of a medicament for dermatological use, particularly for treating skin pathologies where it is essential to block the inflammatory process, by modulating the calcium and free radical channels caused by oxidative processes
Data Source
AI summary
Composition in the form of a cosmetic formulation or dermatological medicament, suitable for maintaining skin cells at, or helping to restore skin cells to, their basal physiological state, enabling them to effect a regeneration of the dermis and the epidermis, comprising: - curcumin - a phosphosaccharide and possibly - a metal or basic oxide, or a biologically acceptable salt thereof, or a labile coordination compound thereof able to form, with at least one of said compounds: complexes, derivatives or associations which enhance their activity, in combination with excipients and/or diluents normally employed for cosmetic or pharmaceutical use.