Curcumin Composition for Neutrophil-to-Lymphocyte Ratio Reduction
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Solution Overview
Problem
There is a lack of a drug capable of effectively decreasing the neutrophil-to-lymphocyte ratio, which is associated with various diseases and poor prognosis, including breast cancer, diabetes, coronary artery disease, chronic inflammation, and COVID-19.
Innovation Solution
A curcumin-based agent or food composition, including curcumin, curcumin derivatives, and conjugates with water-soluble substances, is administered to decrease the neutrophil-to-lymphocyte ratio.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used, then general disease management is maintained, but the neutrophil-to-lymphocyte ratio cannot be decreased
Solution Approach 1:
The patent applies parameter changes by introducing curcumin and its derivatives as a new therapeutic parameter (active ingredient) that specifically targets the neutrophil-to-lymphocyte ratio. The invention changes the chemical composition parameter of the treatment from conventional agents to curcumin-based compounds, which have been shown to decrease the neutrophil-to-lymphocyte ratio and improve disease prognosis in various conditions including cancer and chronic inflammation.
2Reliability
If curcumin is used to decrease neutrophil-to-lymphocyte ratio, then disease prognosis is improved, but water solubility and bioavailability may be limited
Solution Approach 1:
The patent applies composite materials by creating conjugates of curcumin with water-soluble substances. This composite approach combines curcumin (which has the therapeutic effect of decreasing neutrophil-to-lymphocyte ratio) with water-soluble carriers or modifiers, thereby improving the water solubility and bioavailability of curcumin while maintaining its therapeutic effectiveness. The composite structure allows curcumin to be administered more effectively in clinical settings.
Data Source
AI summary
Provided is an agent or a food composition capable of decreasing a neutrophil-to-lymphocyte ratio. An agent for decreasing a neutrophil-to-lymphocyte ratio in blood contains a curcumin as an active ingredient.