Curcumin Bioavailability via Piperine and Oleic Acid
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Solution Overview
Problem
Current treatments for Alzheimer's disease, particularly those involving oral curcumin, face challenges due to poor bioavailability as curcumin is poorly absorbed from the gastrointestinal tract into the bloodstream, limiting its effectiveness in retarding the onset of symptoms.
Innovation Solution
A dietary supplement composition combining curcumin with piperine, oleic acid, oleanolic acid, ursolic acid, galantamine, huperzine A, choline, and vitamin B5, optionally including gamma tocopherol, sesamolin, vinpocetine, and pyritinol, to enhance bioavailability and inhibit β-amyloid aggregation, administered in an orally administrable form.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If curcumin is administered orally as a dietary supplement, then it can potentially retard the onset of Alzheimer's disease symptoms through its antioxidant and anti-inflammatory effects, but its effectiveness is severely limited due to poor absorption from the gastrointestinal tract into the bloodstream
Solution Approach 1:
Piperine is introduced as an intermediary substance that facilitates the absorption of curcumin. The patent specifies that piperine increases curcumin bioavailability by enhancing its uptake from the gastrointestinal tract into the bloodstream, thereby resolving the contradiction between oral administration effectiveness and poor absorption
Solution Approach 2:
The invention creates a composite dietary supplement formulation combining curcumin with piperine and other bioavailability-enhancing substances. This composite approach allows the mixture to achieve superior absorption and effectiveness compared to curcumin alone, addressing the bioavailability limitation while maintaining the therapeutic benefits
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition significantly increases curcumin bioavailability and retards the onset and progression of Alzheimer's disease symptoms by improving nutrient absorption and inhibiting β-amyloid formation, potentially delaying symptom onset by several years.
Implementation Method 1
Piperine, a botanical pepper extract, increases the bioavailability of curcumin in humans by increasing the absorption of curcumin from the gastrointestinal tract
Implementation Method 2
Curcumin exhibits an affinity for β-amyloid and both inhibits the aggregation of β-amyloid fragments into plaque formations as well as dissolves existing β-amyloid plaques
Implementation Method 3
As an antioxidant, curcumin removes harmful free radicals from the body, thereby protecting the human body, and particularly, the brain, by preventing lipid peroxidation
Implementation Method 4
The composition comprises curcumin and piperine, a botanical pepper extract, for increasing the bioavailability of curcumin when said curcumin is orally administered to a patient
Data Source
AI summary
A composition and a method for using the composition to delay the onset of the symptoms of Alzheimer's disease in humans, comprising curcumin, piperine, oleic acid, oleanolic acid, ursolic acid, galantamine, and huperzine A, among other compounds. Curcumin is an antioxidant, while galantamine and huperzine A inhibit the activity of acetylcholinesterase in the brain. Piperine and oleic acid increase the bioavailability and gastrointestinal absorption of curcumin, galantamine, huperzine A, and other nutrients.