Curcumin Bioavailability via Spirulina Composite
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Solution Overview
Problem
Curcumin exhibits low bioavailability due to rapid elimination and intestinal absorption issues, leading to suboptimal blood levels and potential laxative effects, despite previous attempts to improve its bioavailability using piperine and other methods.
Innovation Solution
Combining curcumin with Spirulina or Spirulina extracts in specific weight ratios to enhance bioavailability, allowing for prolonged and stable curcumin absorption in the intestine, as seen in oral pharmaceutical and non-pharmaceutical preparations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If curcumin is administered alone, then the composition is simple, but the bioavailability is low due to rapid elimination and poor intestinal absorption
Solution Approach 1:
The patent combines curcumin with Spirulina (a blue-green algae) to create a composite composition. This composite approach leverages the synergistic effects between curcumin and Spirulina components, where Spirulina provides nutrients and compounds that enhance curcumin absorption and reduce elimination, thereby improving bioavailability while maintaining a relatively simple natural composition structure.
2Reliability
If piperine is used to inhibit curcumin elimination, then bioavailability increases, but intestinal irritation occurs
Solution Approach 1:
The patent uses Spirulina as an intermediary substance to improve curcumin bioavailability. Instead of using piperine which directly irritates the intestine, Spirulina acts as a mediator that enhances absorption through its nutritional components and bioactive compounds, achieving the same goal of improved bioavailability without the harmful side effects of intestinal irritation.
3Reliability
If curcumin concentration in blood is increased, then therapeutic effect improves, but laxative effects occur
Solution Approach 1:
The patent changes the parameter of curcumin delivery by combining it with Spirulina, which modifies the pharmacokinetic profile. This combination allows achieving therapeutic blood concentrations of curcumin while the Spirulina components modulate absorption and elimination rates, preventing the excessive concentrations that cause laxative effects.
4Productivity
If curcumin is rapidly eliminated by the body, then metabolism is efficient, but bioavailability decreases
Solution Approach 1:
The patent converts the rapid elimination characteristic of curcumin from a harmful factor into a benefit by combining it with Spirulina. The Spirulina components interact with curcumin metabolism pathways, extending its presence in the body while maintaining efficient metabolic processing. This transforms the rapid elimination issue into an opportunity for controlled, sustained release and action.
Data Source
AI summary
The pharmaceutical or non-pharmaceutical use of an effective amount of Spirulina and/or of an extract/extracts of Spirulina for improving the bioavailability of orally administered curcumin in humans or animals. Pharmaceutical or non-pharmaceutical preparations including Spirulina and/or extracts of Spirulina containing curcumin having improved bioavailability.