Curcuminoid-Anionic Surfactant Complex for Oral Care Stability
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Solution Overview
Problem
Current oral care compositions containing curcuminoids face stability issues, leading to reduced efficacy and manufacturing challenges.
Innovation Solution
The development of oral care compositions that include a complex or conjugate of a curcuminoid with an anionic surfactant, such as an alkyl sulfate surfactant, which enhances stability and diffusion properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If curcuminoid-containing compositions are used in oral care, then anti-inflammatory and antibacterial efficacy is achieved, but stability issues arise leading to reduced efficacy over time
Solution Approach 1:
The patent uses an anionic surfactant as an intermediary substance to stabilize curcuminoid. The surfactant forms a complex with curcuminoid, preventing its degradation while maintaining its anti-inflammatory and antibacterial properties. This mediator approach resolves the contradiction by introducing a third substance that protects the active ingredient without compromising its efficacy.
Solution Approach 2:
The patent creates a composite formulation by combining curcuminoid with anionic surfactant in specific ratios. This composite material approach enhances the stability of curcuminoid while preserving its biological activity, effectively resolving the contradiction between stability and efficacy.
2Reliability
If curcuminoid-containing compositions are used, then therapeutic benefits are achieved, but manufacturing challenges increase due to stability issues
Solution Approach 1:
The anionic surfactant serves as a manufacturing-friendly intermediary that simplifies the formulation process. By using surfactant-curcuminoid complexes, the patent enables more reliable and scalable manufacturing while maintaining therapeutic benefits, as the complex is more stable during production and storage.
3Reliability
If curcuminoid is added to oral care composition, then anti-inflammatory activity against periodontal disease is achieved, but composition stability deteriorates
Solution Approach 1:
The anionic surfactant acts as a protective intermediary that stabilizes curcuminoid in the oral care composition. The surfactant-curcuminoid complex maintains anti-inflammatory activity against periodontal disease while significantly improving composition stability during storage and use.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The proposed solution significantly improves the stability of curcuminoids in oral care compositions, maintaining efficacy over time and simplifying manufacturing processes.
Implementation Method 1
a complex comprising: a curcuminoid; and an anionic surfactant
Implementation Method 2
an anionic surfactant
Implementation Method 3
the conjugate has a diffusion coefficient less than the diffusion coefficient of the curcuminoid alone
Data Source
AI summary
Described herein are—inter alia—complexes comprising a curcuminoid; and an anionic surfactant. Methods of making and using same are also described.