Curcuminoid Composition Water Solubility via Comminution

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Solution Overview

Problem

Conventional methods for producing curcuminoids result in poorly water-soluble extracts that aggregate when mixed with aqueous liquids, making it difficult to incorporate them into comestibles.

Innovation Solution

A method involving the preparation of a dispersible curcuminoid composition by extracting curcuminoids from turmeric root, drying the slurry, comminuting the dried composition, and blending it with an emulsifier to enhance water solubility and stability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If conventional extraction methods are used to produce curcuminoid extracts, then the extraction process is simple, but the resulting extract aggregates when mixed with aqueous liquids and is poorly water-soluble

Engineering Contradiction:
Improveextraction process simplicityVSAvoidwater solubility and dispersion stability
Core Design Contradiction:
Ease of manufactureVSStability of the object's composition

Solution Approach 1:

The patent segments the curcuminoid extract into fine particles through comminution, reducing particle size from conventional extract forms to nanoscale or fine particulate forms. This segmentation increases surface area and prevents aggregation in aqueous solutions, directly resolving the water solubility issue while maintaining extraction simplicity

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent creates a composite structure by combining curcuminoid particles with carrier materials or surface modification agents. This composite approach enhances water dispersibility and stability while preserving the core curcuminoid extraction process, effectively resolving the contradiction between simple extraction and stable aqueous dispersion

Inventive Principle:
Principle #40Composite materials

2Productivity

If curcuminoid extracts are prepared using conventional methods, then the production process is straightforward, but the extracts aggregate and form unstable suspensions in aqueous liquids

Engineering Contradiction:
Improveproduction efficiencyVSAvoidsusension stability
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The patent applies preliminary comminution and surface treatment to the curcuminoid extract before it is used in aqueous formulations. This preliminary action prevents aggregation and ensures stable suspension formation, improving reliability without significantly impacting production efficiency

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent changes physical parameters of the extract such as particle size, surface area, and surface charge through controlled comminution and treatment processes. These parameter changes transform the extract from aggregation-prone to stable aqueous-dispersible, resolving the reliability issue while maintaining productivity

Inventive Principle:
Principle #35Parameter changes

3Device complexity

If conventional extraction and purification methods are used, then the process requires fewer steps, but the resulting composition is not highly dispersible in water

Engineering Contradiction:
Improveprocess step numberVSAvoidwater dispersibility
Core Design Contradiction:
Device complexityVSEase of operation

Solution Approach 1:

The patent introduces a comminution step that segments the extract into fine particles, dramatically improving water dispersibility. Although this adds a processing step, the segmentation process is relatively simple and can be integrated into existing workflows, providing high dispersibility with minimal increase in process complexity

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent uses carrier materials or surface modification agents as intermediaries to bridge the curcuminoid particles and aqueous environment. These intermediaries facilitate water dispersibility without requiring complex purification or extraction process changes, effectively improving ease of operation with minimal device complexity increase

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method produces a curcuminoid composition that is highly dispersible in water, allowing for a uniform suspension in aqueous liquids and extended stability, suitable for comestible applications.

Implementation Method 1

extracting curcuminoids from the particulate source into an extraction solvent

Methodology Applied
Scientific EffectLiquid-liquid extraction: Liquid-Liquid Extraction

Implementation Method 2

removing at least a portion of the extraction solvent to provide a curcuminoid slurry

Methodology Applied
Scientific EffectEvaporation: Evaporation

Data Source

PatentUS11413257B2Methods for preparing curcuminoid compositions
Publication Date: 2022.08.16 LODAAT PHARMA
  • US11413257B2 patent drawing
  • US11413257B2 patent drawing
  • US11413257B2 patent drawing

AI summary

The invention relates to methods for preparing dispersible curcuminoid compositions.