Curcuminoid Isolation via High-Concentration Ethanol Extraction
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Solution Overview
Problem
Conventional methods for isolating curcuminoids from turmeric rhizome are inefficient, environmentally harmful, and costly due to the use of organic solvents, requiring multiple extractions and complex processes.
Innovation Solution
A method involving extraction with a 90-100% ethanol solution at specific stirring speeds and subsequent crystallization with a second ethanol solution at controlled temperatures to obtain curcuminoids efficiently and with high purity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If conventional organic solvents (acetone or isopropanol) are used for extraction, then curcuminoids can be obtained, but the process becomes harmful to environment and human health
Solution Approach 1:
The patent changes the chemical parameter of the extraction solvent from conventional organic solvents (acetone, isopropanol) to high-concentration ethanol (90-100%), which maintains extraction effectiveness while eliminating environmental and health hazards associated with traditional solvents
Solution Approach 2:
The patent converts the potential disadvantage of ethanol (lower extraction efficiency compared to some organic solvents) into a benefit by using high-concentration ethanol (90-100%) combined with optimized stirring parameters, achieving both high curcuminoid yield and environmental safety
2Productivity
If multiple extractions or ultrasonic extraction are used to improve curcuminoid yield, then extraction efficiency increases, but the process becomes cumbersome and time consuming
Solution Approach 1:
The patent optimizes extraction parameters including stirring speed (100-300 rpm), temperature (20-40°C), and solvent concentration (90-100% ethanol) to achieve high curcuminoid extraction efficiency in a single step, eliminating the need for multiple extractions
Solution Approach 2:
The patent performs preliminary optimization of extraction conditions before the actual extraction process, determining the optimal combination of ethanol concentration, stirring speed, and temperature to ensure maximum efficiency in a single extraction operation
3Manufacturing precision
If conventional extraction methods are used, then the process can be completed, but further purification steps are required which increase cost and complexity
Solution Approach 1:
The patent utilizes phase transition (crystallization) of curcuminoids from the ethanol extract by controlling temperature and concentration, enabling direct purification to high purity curcuminoid crystals without requiring additional complex purification equipment or steps
Solution Approach 2:
The patent extracts curcuminoids directly into ethanol and then isolates them through crystallization, taking out the pure curcuminoid product in a single operation without requiring multiple sequential purification steps
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method achieves a higher yield and simpler operation, reducing costs and environmental impact while maintaining high curcuminoid content and purity.
Implementation Method 1
subjecting the turmeric rhizome to extraction with a first ethanol solution having an ethanol concentration ranging from 90% to 100%
Implementation Method 2
extraction with a first ethanol solution... so as to obtain an ethanol-extracted product
Implementation Method 3
subjecting the ethanol-extracted product to crystallization with a second ethanol solution having an ethanol concentration ranging from 90% to 100% at a temperature ranging from 2°C to 8°C
Data Source
AI summary
A method for isolating curcuminoids from turmeric rhizome includes the steps of a) subjecting the turmeric rhizome to extraction with a first ethanol solution having an ethanol concentration ranging from 90% to 100% at a stirring speed ranging from 100 rpm to 300 rpm so as to obtain an ethanolextracted product; and b) subjecting the ethanolextracted product to crystallization with a second ethanol solution having an ethanol concentration ranging from 90% to 100% at a temperature ranging from 2°C to 8°C and a stirring speed ranging from 40 rpm to 300 rpm so as to obtain the curcuminoids.