Curcuminoid Bioavailability via Phytosome and Cyclodextrin Complexation
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Solution Overview
Problem
Curcuminoids, particularly curcumin, suffer from limited bioavailability due to poor solubility in water, rapid metabolism, and poor intestinal absorption, which hampers their therapeutic potential in treating various human diseases.
Innovation Solution
A composition comprising curcuminoids, an extract from quillaja, and modified starch or gum arabic is administered to improve the bioaccessibility, bioavailability, bioefficacy, and bioactivity of curcuminoids in mammals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If curcuminoids are administered orally, then therapeutic effects are achieved, but bioavailability is limited due to poor solubility and rapid metabolism
Solution Approach 1:
The patent uses a composite delivery system comprising curcuminoids combined with phospholipids (forming phytosomes), cyclodextrins, and/or liposomes. This composite structure improves solubility and protects curcuminoids from rapid metabolism, thereby enhancing bioavailability while maintaining therapeutic efficacy.
Solution Approach 2:
The patent introduces intermediary substances (phospholipids, cyclodextrins, liposomes) that act as carriers or solubilizing agents for curcuminoids. These intermediaries facilitate absorption by intestinal cells and protect the active compounds from degradation, resolving the contradiction between therapeutic effect and bioavailability.
2Reliability
If curcuminoids are used to treat diseases, then therapeutic potential is realized, but solubility in water is poor
Solution Approach 1:
The patent changes the physical and chemical parameters of curcuminoid delivery by forming complexes with phospholipids, cyclodextrins, and liposomes. These parameter changes include altering solubility characteristics, molecular association state, and stability profiles, thereby enabling therapeutic use while overcoming poor water solubility.
Solution Approach 2:
The patent creates composite materials where curcuminoids are combined with solubilizing agents (phospholipids, cyclodextrins, liposomes). This composite approach maintains the therapeutic properties of curcuminoids while dramatically improving their solubility in aqueous environments through the properties of the carrier materials.
3Reliability
If curcuminoids are administered, then biological activity is achieved, but intestinal absorption is poor
Solution Approach 1:
The patent uses intermediary delivery systems (phytosomes, cyclodextrin complexes, liposomes) that facilitate intestinal absorption. These intermediaries enhance permeability through intestinal epithelium and protect curcuminoids from degradation during transit, thereby improving ease of absorption while maintaining bioactivity.
Solution Approach 2:
The patent modifies absorption parameters by changing the physical state and molecular characteristics of curcuminoids through complexation with phospholipids, cyclodextrins, and liposomes. These parameter changes include improving membrane permeability, reducing molecular size for easier transport, and protecting against efflux mechanisms, thereby enhancing intestinal absorption.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition significantly enhances the gastrointestinal resistance and absorption of curcuminoids by intestinal cells, leading to improved bioavailability and therapeutic efficacy.
Implementation Method 1
Curcuminoids, particularly curcumin, suffer from limited bioavailability due to poor solubility in water
Implementation Method 2
The composition significantly enhances the gastrointestinal resistance and absorption of curcuminoids by intestinal cells
Data Source
AI summary
The present invention relates to methods and uses of compositions comprising curcumin; in particular, methods and uses relating to improving the bioaccessibility, bioavailability, bioefficacy and/or bioactivity of curcuminoids in mammals.