Graphical Indicators for Parameter Independence in Curve Fit Analysis

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Solution Overview

Problem

Researchers face challenges in identifying unreliable parameters in curve fit functions used for dose-response data analysis, as high standard error and confidence interval values are often overlooked, leading to potential issues with curve fit choice or data quality.

Innovation Solution

A system and method that determine parameter dependence and independence values, generating graphical indicators to alert researchers to unreliable parameters, allowing for re-evaluation of curve fits or data collection strategies.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If researchers use regression analysis to fit curve functions to dose-response data, then they can obtain parameter estimates, but the parameters may have high standard error and confidence interval values indicating unreliability

Engineering Contradiction:
Improveparameter reliabilityVSAvoidparameter confidence
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

The patent introduces graphical indicators as intermediary visual elements between the raw parameter data and the researcher's interpretation. These indicators mediate the communication of parameter reliability by translating numerical confidence interval and standard error values into intuitive visual representations, enabling researchers to quickly assess parameter quality without deeply analyzing the underlying statistics

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent employs color-coded graphical indicators to represent different levels of parameter reliability. By using color changes or color variations in the graphical indicators, the system provides an intuitive visual coding scheme where researchers can immediately distinguish between reliable and unreliable parameters through color perception, enhancing the communication of statistical confidence without requiring numerical literacy

Inventive Principle:
Principle #32Color changes

2Productivity

If researchers focus on the curve fit function parameters, then they can perform data analysis, but they may fail to recognize the significance of high standard error and confidence interval values

Engineering Contradiction:
Improvedata analysis efficiencyVSAvoidparameter reliability information
Core Design Contradiction:
ProductivityVSLoss of information

Solution Approach 1:

The patent segments the parameter information into two distinct visual components: the parameter estimate value and the graphical indicator of reliability. This segmentation allows the curve fit function to be displayed with its parameters, while simultaneously presenting reliability information through separate graphical indicators, preventing the loss of reliability information while maintaining analysis efficiency

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent adds a visual dimension to the traditional numerical parameter display by incorporating graphical indicators that represent reliability information. This dimensional enhancement transforms the one-dimensional numerical output into a two-dimensional visual representation that simultaneously conveys both parameter values and their reliability, making the significance of confidence intervals immediately apparent to researchers

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Data Source

PatentUS9007377B2System and method for displaying parameter independence in a data analysis system
Publication Date: 2015.04.14 MOLECULAR DEVICES LLC
  • US9007377B2 patent drawing
  • US9007377B2 patent drawing
  • US9007377B2 patent drawing

AI summary

A system for performing a data analysis is provided. The system includes a curve fit module that determines a curve fit function for a data set. A parameter dependence determination module determines a dependence value for a parameter of the curve fit function. A parameter independence determination module determines an independence value for the parameter of the curve fit function based on the dependence value for the parameter. A graphical indicator generation module generates a graphical indicator for the parameter. The graphical indicator corresponds to the independence value for the parameter.