Curved Adapter for Magnetic Particle Separation
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Solution Overview
Problem
Current devices for isolating target analytes from liquid samples are inefficient in separating magnetic particles from other components, leading to contamination and suboptimal processing outcomes.
Innovation Solution
A sample processing system with a sliding head and adapter that uses a magnet to move magnetic particles between wells, allowing for effective isolation and processing of target analytes while minimizing liquid carryover and contamination.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If magnetic particles are separated from liquid samples using conventional devices, then target analytes can be isolated, but contamination and suboptimal processing outcomes occur due to inefficient separation
Solution Approach 1:
The adapter bottom surface features a curved configuration with a radius of curvature between 0.25 to 0.75 inches that conforms to the meniscus of liquid in sample wells. This curvature enables the magnet to closely approach the liquid surface, maximizing magnetic field strength at the liquid interface while preventing liquid carryover through proper contact geometry, thereby achieving efficient separation without contamination
2Reliability
If the magnet is positioned close to the liquid surface for effective particle separation, then separation efficiency improves, but liquid carryover increases
Solution Approach 1:
The curved bottom surface of the adapter creates an optimal geometric relationship between the magnet and liquid meniscus. The specific radius of curvature (0.25-0.75 inches) allows the magnet to approach within 0.004 to 0.020 inches of the liquid surface, generating sufficient magnetic force for effective particle separation while the curved geometry prevents liquid from bridging to the magnet, thus eliminating carryover
Solution Approach 2:
The adapter design creates different functional zones: the curved bottom surface area contacts the liquid meniscus for optimal magnetic separation, while the elevated peripheral areas prevent liquid contact with the magnet. This spatial differentiation of functions allows simultaneous achievement of high separation efficiency and zero liquid carryover
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enables efficient isolation and processing of target analytes by minimizing contamination and optimizing the recovery of magnetic particles, facilitating further analysis.
Implementation Method 1
The magnet is mounted in the housing to extend through the base... uses a magnet to move magnetic particles between wells
Implementation Method 2
At least a portion of the bottom surface is curved and comprises a ridge having a bottom surface for contacting a liquid on a sample plate, the curvature of the bottom surface being convex with respect to the sample plate... minimizing liquid carryover
Data Source
Figure 1A
Figure 1B
Figure 1C
AI summary
An adapter for a sliding head of a sample processing system is provided that includes a plate and a magnet mounting recess wall. The plate includes a top surface, a bottom surface, a front wall extending between the top surface and the bottom surface, and a back wall extending between the top surface and the bottom surface. The magnet mounting recess wall is mounted to the top surface. The magnet mounting recess wall is configured to accommodate a magnet of a sliding head of a sample processing system. At least a portion of the bottom surface is curved in a first direction from the front wall to the back wall and is concave relative to the top surface.