Custom Brachytherapy Carriers for Real-Time Conformal Dosimetry
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Solution Overview
Problem
Current brachytherapy devices are inadequate for treating highly variable tumors due to their inability to accommodate anatomically conformal and reproducible brachytherapy doses, lack of real-time dosimetric customization for sparing normal tissue, and inability to incorporate additional therapeutic agents.
Innovation Solution
A specialized loading device for brachytherapy carriers that allows for real-time customization of radionuclide carriers, providing precise and predictable dosimetry, and the ability to incorporate chemotherapy, viral, and DNA damage repair inhibitors, while shielding users from radiation exposure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If current brachytherapy devices are used, then treatment can be provided, but the devices cannot accommodate anatomically conformal and reproducible brachytherapy doses for highly variable tumors
Solution Approach 1:
The brachytherapy device incorporates adjustable and reconfigurable components that allow dynamic adaptation to different tumor geometries and positions. The device enables real-time modification of carrier configurations and radiation source placements to achieve anatomically conformal dosing for highly variable tumors while maintaining precise dosimetric control through programmable positioning systems.
2Adaptability or versatility
If current brachytherapy devices are used, then treatment can be provided, but real-time dosimetric customization for sparing normal tissue is not possible
Solution Approach 1:
The device enables pre-planning and pre-configuring of brachytherapy carriers and radiation sources based on patient-specific imaging and dosimetric requirements. Treatment parameters, carrier positions, and radiation source placements can be predetermined and optimized before the procedure, allowing for real-time execution with minimal adjustment time while achieving customized dosing that spares normal tissue.
3Adaptability or versatility
If current brachytherapy devices are used, then treatment can be provided, but additional therapeutic agents cannot be incorporated
Solution Approach 1:
The brachytherapy device is designed as a multi-functional platform that can incorporate not only radiation sources but also carriers for additional therapeutic agents such as chemotherapy drugs, viral vectors, and DNA damage repair inhibitors. The device structure includes integrated compartments and delivery mechanisms that allow simultaneous administration of multiple therapeutic modalities, expanding treatment versatility without requiring separate devices for each function.
Data Source
AI summary
Carriers for embodying radioactive seeds, as well as a device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present disclosure relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.