Cyclanthera pedata Extracts for Cholesterol Management

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Solution Overview

Problem

Current treatments for atherosclerosis and hypercholesterolemia often come with side effects and limited efficacy, as existing drugs only partially address the issue of lowering LDL cholesterol and do not effectively reduce oxidized LDL, which is a major contributor to atherosclerosis progression.

Innovation Solution

The use of Cyclanthera pedata plant extracts, obtained through polar organic solvent extraction, which are formulated into dietary supplements or pharmaceutical compositions to inhibit cholesterol biosynthesis and reduce serum cholesterol levels, including oxidized LDL, without the side effects associated with traditional medications.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional cholesterol-lowering drugs are used, then LDL cholesterol levels are partially reduced, but oxidized LDL levels are not effectively reduced and side effects occur

Engineering Contradiction:

ImproveLDL cholesterol levelsVSAvoidefficacy in reducing oxidized LDL

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent changes the chemical parameters of the extraction process by using polar organic solvents with specific polarity ranges (dielectric constant 15-40) to selectively extract compounds that address oxidized LDL reduction, rather than using conventional extraction methods. This parameter change enables the extraction of specific bioactive compounds from Cyclanthera pedata that target oxidized LDL.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite extract containing multiple bioactive compounds from Cyclanthera pedata (including cucurbitacins, saponins, and other phytochemicals) that work synergistically to reduce both LDL and oxidized LDL levels, providing enhanced efficacy compared to single-compound conventional drugs.

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If conventional cholesterol-lowering drugs are used, then some cholesterol reduction is achieved, but adverse effects are produced

Engineering Contradiction:

Improvetotal cholesterol levelsVSAvoidside effects

Core Design Contradiction:

Quantity of substanceVSObject-generated harmful factors

Solution Approach 1:

The patent uses natural plant extracts from Cyclanthera pedata as a temporary, renewable alternative to long-term conventional pharmaceutical interventions. The extract provides cholesterol-lowering effects through natural compounds that can be replenished through continuous plant cultivation, avoiding the accumulation of synthetic drug metabolites that cause side effects.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent converts the potentially harmful oxidized LDL into a beneficial target for treatment by using plant compounds that specifically reduce oxidized LDL levels. The oxidized LDL, which is a major contributor to atherosclerosis progression, becomes the focus of the therapeutic action rather than just a byproduct to be ignored.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Manufacturing precision

If polar organic solvent extraction is used, then selective extraction of bioactive compounds is achieved, but extraction process complexity increases

Engineering Contradiction:

Improveselectivity of extract compositionVSAvoidextraction process complexity

Core Design Contradiction:

Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent simplifies the extraction process by focusing on changing key parameters (solvent polarity, temperature, extraction time) rather than using complex multi-step procedures. By selecting polar organic solvents with specific dielectric constants (15-40) and controlling extraction conditions, the method achieves selective extraction of bioactive compounds through straightforward parameter optimization.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The Cyclanthera pedata extracts effectively lower total cholesterol, LDL, and oxidized LDL levels, while raising HDL levels, thereby reducing the risk of atherosclerosis progression without the adverse effects seen with conventional therapies, as demonstrated in clinical studies.

Implementation Method 1

The present invention provides a composition obtained by polar organic solvent extraction of plant material derived from the Cyclanthera pedata plant

Methodology Applied

Scientific EffectSolvation: Solvation

Data Source

PatentUS10967027B2Extracts of <i>Cyclanthera pedata </i>and formulations and uses thereof

Publication Date: 2021.04.06 PROCAPS

AI summary

The invention provides a method for extracting active therapeutic components from plant materials of the cyclanthera pedata plant which comprises immersing said plant material containing active components and selected from the group consisting of fruits, flowers, leaves, stems, twigs, bark, wood, buds, seeds, roots, and pods in a solvent for a period of time of about 30 minutes to about 10 hours to achieve transfer of active components from the plant material to the solvent, separating the solvent containing active components from the plant material, and evaporating or distilling the solvent to produce a concentrated fraction containing active components. The invention further includes compositions and therapeutic formulations of such extracts to treat hypercholesterolemia and other high lipid related diseases.