Cyclic Amine Derivatives for Advillin-Mediated Axon Regrowth
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Solution Overview
Problem
There is a lack of effective therapeutic agents that promote advillin function to enhance axon extension and improve actin filament turnover, leading to incomplete functional recovery after axonal injury of peripheral nerves, such as those caused by surgical operations, toxic substances, or radiation therapy.
Innovation Solution
A cyclic amine derivative or its pharmacologically acceptable salt, represented by a specific general formula, is used to promote advillin function by binding to advillin and/or its complexes, thereby improving actin filament turnover and promoting axon extension.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If axonal regeneration is allowed to occur naturally after axonal injury, then the axon can attempt to regrow, but the surrounding tissues and target tissues degenerate during the regeneration time, resulting in inaccurate rejoining and incomplete functional recovery
Solution Approach 1:
The patent applies preliminary action by administering the cyclic amine derivative before or at the time of axonal injury to prevent tissue degeneration during the regeneration period. The compound maintains tissue integrity and target tissue viability in advance, creating optimal conditions for accurate axon rejoining when regeneration occurs.
Solution Approach 2:
The cyclic amine derivative acts as an intermediary substance that mediates between the axon regeneration process and the surrounding/target tissues. It protects the tissues from degeneration while allowing axon regeneration to proceed, enabling both speed and accuracy of rejoining.
2Reliability
If surgical nerve repair or function reconstructive surgery is performed to treat axonal injury, then functional recovery can be improved, but the patient bears a large burden
Solution Approach 1:
The patent applies self-service by enabling the body's own axons to regenerate and recover function through the pharmacological action of the cyclic amine derivative. The compound stimulates endogenous repair mechanisms, eliminating the need for invasive surgical interventions and reducing patient burden while maintaining functional recovery.
3Speed
If advillin function is enhanced to promote axon extension, then axon regeneration speed increases, but there is a lack of effective therapeutic agents to achieve this
Solution Approach 1:
The patent applies parameter changes by identifying and optimizing the chemical structure of cyclic amine derivatives to achieve optimal advillin function promotion. By modifying molecular parameters (structure, stereochemistry, substituents), the patent creates compounds with enhanced ability to promote axon extension and actin filament turnover.
Solution Approach 2:
The cyclic amine derivative serves as a chemical intermediary that transmits the effect of promoting advillin function to enhance axon extension. The compound mediates between the cellular machinery and the desired outcome of accelerated axon regeneration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cyclic amine derivative effectively enhances axon extension and normalizes actin filament turnover, facilitating accurate rejoining of axons to target tissues and reducing abnormal perceptions or involuntary movements following axonal injuries.
Implementation Method 1
promote advillin function by binding to advillin and/or its complexes
Data Source
AI summary
An agent for promoting advillin function, the agent including a low molecular weight compound, and is useful for treatment of axonal injury. In some instances, the agent for promoting advillin function, includes a cyclic amine derivative typically represented by the following chemical formula, or a pharmacologically acceptable salt thereof as an active ingredient.