Cross-linked cyclic amine compounds for pest control
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Solution Overview
Problem
Conventional pest control compounds face issues such as insufficient efficacy, drug resistance, phytotoxicity, and toxicity to mammals and fish, limiting their industrial synthesis and safe use for pest control.
Innovation Solution
Development of novel cyclic amine compounds with specific structures that exhibit excellent insecticidal and acaricidal activities, including salts and N-oxides, which can be used as active ingredients in pest control agents, providing high safety and effectiveness against crop-damaging insects and acarids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional pest control compounds are used, then pest control effect is achieved, but drug resistance occurs and efficacy becomes insufficient
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of pest control compounds through cross-linking cyclic amine structures with specific substituents (aromatic rings, heterocyclic groups, and linker groups). This structural parameter change creates novel compounds with improved efficacy and reduced resistance development compared to conventional compounds.
Solution Approach 2:
The patent employs composite materials by creating cross-linked cyclic amine compounds that combine multiple functional groups (cyclic amine core, aromatic substituents, heterocyclic groups, and linker groups) into a single molecular structure. This composite approach enhances pest control effectiveness while addressing drug resistance issues.
2Reliability
If conventional pest control compounds are used, then pest control activity is achieved, but phytotoxicity and contamination in plant bodies occur
Solution Approach 1:
The patent applies local quality by introducing specific functional groups at particular positions on the cyclic amine structure (such as aromatic rings at N-substituent positions and heterocyclic groups at C-substituent positions). This localized structural modification targets pest control activity while minimizing harmful effects on plants.
3Reliability
If conventional pest control compounds are used, then pest control effect is achieved, but strong toxicity against mammals and fish occurs
Solution Approach 1:
The patent uses parameter changes by modifying molecular parameters of pest control compounds through cross-linking cyclic amine structures with specific aromatic and heterocyclic substituents. These parameter modifications maintain high pest control activity while reducing toxicity to non-target organisms such as mammals and fish.
4Reliability
If novel cyclic amine compounds with specific structures are developed, then excellent insecticidal and acaricidal activities are achieved, but industrial synthesis favorability must be maintained
Solution Approach 1:
The patent applies segmentation by dividing the complex cyclic amine structure into modular components (cyclic amine core, aromatic substituents, heterocyclic groups, and linker groups) that can be synthesized separately and then assembled. This modular approach facilitates industrial synthesis while maintaining the bioactive structure.
Data Source
AI summary
Cyclic amine compounds represented by formula (1) or salts thereof or N-oxides thereof, wherein Cy1 represents an unsubstituted or substituted aromatic ring; X represents oxygen, sulfur, unsubstituted or substituted nitrogen, sulfinyl, or sulfonyl; R1a and R2a, R1a and R4a, R2a and R3a, or R3 and R4a form saturated rings together; R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, and R5 which do not form the saturated rings are each independently hydrogen, hydroxyl, halogen, unsubstituted or substituted amino, nitro, or an organic group; Cy2 represents an unsubstituted or substituted aromatic ring with a proviso that Cy2 is an unsubstituted or substituted heteroaromatic ring when R1a and R2a form a saturated ring together and Cy1 is an unsubstituted or substituted phenyl, and Cy2 is a substituted pyridin-2-yl having one or more cyano as a substituent when Cy1 is an unsubstituted or substituted phenyl and Cy2 is a pyridin-2-yl.