Cyclic Amine Insecticides With Tuned Substituents for Specificity
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing pesticidal compounds for controlling pests such as insects and arthropods are inadequate in efficacy and specificity, particularly in agricultural applications.
Innovation Solution
Development of novel pesticidally active azetidinyl, piperidinyl, and piperazinyl aryl carbonyl compounds with specific structural modifications, including various substituents and potential salt forms, to enhance their acaricidal and insecticidal properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing pesticidal compounds are used, then pest control is provided, but efficacy and specificity are inadequate
Solution Approach 1:
The patent introduces specific substituent groups (R1-R5) at different positions on the aromatic ring and cyclic amine structure, creating localized variations in molecular properties. This allows optimization of both efficacy (through electron-withdrawing groups like CN and halogens) and specificity (through spatial arrangement and steric effects), resolving the contradiction between general effectiveness and targeted action.
Solution Approach 2:
The patent systematically varies chemical parameters including substituent types (cyano, halo, alkoxy), ring sizes (azetidinyl, piperidinyl, piperazinyl), and linkage positions to optimize both pesticidal efficacy and specificity. By changing molecular parameters such as electron density distribution and steric configuration, the compounds achieve enhanced reliability while maintaining adaptability to different pest targets.
2Reliability
If novel compounds with specific structural modifications are developed, then acaricidal and insecticidal properties are enhanced, but compound complexity increases
Solution Approach 1:
The patent designs a universal molecular scaffold (aryl carbonyl connected to cyclic amine) that can perform multiple pesticidal functions. By varying substituents R1-R5 on this core structure, the same basic framework achieves both acaricidal and insecticidal activity, reducing the need for entirely separate compound classes and managing complexity through a unified structural platform.
Solution Approach 2:
The complex molecule is divided into functional segments: the aromatic ring system (providing structural stability), the carbonyl linker (providing connectivity), and the cyclic amine (providing basicity and binding capability). Each segment can be independently optimized through substituent selection, allowing enhanced pesticidal properties while managing overall complexity through modular design.
Data Source
AI summary
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.