Cyclic Amine Pesticides for Broad-Spectrum Pest Control
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Solution Overview
Problem
Current pesticidally active compounds for controlling animal pests, particularly insects and arthropods, have limitations in efficacy and specificity, necessitating the development of novel cyclic amine compounds with improved pest control capabilities.
Innovation Solution
The development of novel cyclic amine compounds, specifically azetidinyl-, pyrrolidinyl-, piperdinyl-, and piperazinyl-pyridinyl carbonyl compounds with specific structural modifications, including variations in R1, R2, R3, R4, Z, Q, and substituents, which form acid addition salts or bases for enhanced pesticidal activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current pesticidally active compounds are used for controlling animal pests, then pest control is achieved, but efficacy and specificity are limited
Solution Approach 1:
The patent applies parameter changes by systematically modifying the chemical structure of pesticidal compounds through varying substituents R1-R8, cyclic amine structures (azetidinyl, pyrrolidinyl, piperdinyl, piperazinyl), and carbonyl group configurations. These structural parameter changes generate a series of novel compounds with improved pest control efficacy and broader spectrum of activity while maintaining the core molecular framework
Solution Approach 2:
The invention creates composite molecular structures by combining multiple functional groups and heterocyclic rings into a single pesticidal agent. The compounds integrate electron-withdrawing groups (R1), aromatic or heteroaromatic rings (R4), cyclic amine moieties (Q), and carbonyl functionalities, forming composite molecular architectures that enhance both efficacy and specificity against target pests
2Adaptability or versatility
If novel cyclic amine compounds with specific structural modifications are developed, then broader spectrum of activity is achieved, but compound complexity increases
Solution Approach 1:
The patent segments the molecular structure into distinct functional domains: R1-R4 groups for electronic and steric properties, the carbonyl group for hydrogen bonding and polarity, the cyclic amine Q for basicity and metal coordination, and R5-R8 substituents for fine-tuning activity. This segmentation allows systematic optimization of each domain independently while maintaining overall molecular integrity
Solution Approach 2:
The core molecular framework serves multiple functions simultaneously: the electron-withdrawing group R1 enhances electrophilicity, the aromatic ring R4 provides structural rigidity and pi-stacking interactions, the cyclic amine Q contributes basicity and potential metal binding, and the carbonyl group enables hydrogen bonding. This multi-functionality within a unified structure achieves broad pest spectrum without excessive complexity
Data Source
AI summary
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.