Cyclic Olefin Resin Containers for Ophthalmic Compositions
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Solution Overview
Problem
Ophthalmic compositions containing terpenoid, tocopherol, and/or benzyl ammonium compounds tend to exhibit easy wetting with commonly used resin containers, leading to liquid residue issues and reduced performance.
Innovation Solution
Incorporating these components into ophthalmic compositions with containers made from cyclic olefin resins, along with a buffer, to increase the dynamic contact angle and suppress wetting, thereby improving liquid cutting and maintaining aromaticity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If terpenoid, tocopherol, and/or benzyl ammonium compound are contained in an ophthalmic composition, then the composition has desired pharmacological effects, but wetting to commonly used resin containers occurs easily leading to liquid residue
Solution Approach 1:
The patent changes the material parameter of the container from commonly used resins (polypropylene, polyethylene, polyethylene terephthalate) to a resin containing a cyclic olefin polymer or copolymer. This material parameter change increases the dynamic contact angle of the ophthalmic composition, suppressing wetting and preventing liquid residue while maintaining the pharmacological effectiveness of terpenoid, tocopherol, and/or benzyl ammonium compound.
2Object-generated harmful factors
If the ophthalmic composition is contained in a container formed from a resin containing a cyclic olefin, then wetting is suppressed and liquid cutting is improved, but aromaticity is reduced or odor is deteriorated during preservation
Solution Approach 1:
The patent introduces a buffer as an intermediary substance in the ophthalmic composition. This buffer acts as a mediator that stabilizes the composition during preservation, preventing the reduction of aromaticity and odor deterioration that would otherwise occur when the composition is stored in a cyclic olefin-containing resin container. The buffer compensates for the interaction between the composition and the container material.
3Ease of manufacture
If commonly used resin containers are used, then manufacturing is simple and cost-effective, but dynamic contact angle is small leading to easy wetting
Solution Approach 1:
The patent changes the material parameter of the container from commonly used resins to a resin containing a cyclic olefin polymer or copolymer. This change in material composition increases the dynamic contact angle, improving the wetting characteristics and liquid cutting performance while maintaining manufacturability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively reduces liquid residue and improves liquid cutting performance while maintaining the aromaticity of the ophthalmic composition, enhancing its quality and usability.
Implementation Method 1
the dynamic contact angle to resins widely used is small, and wetting occurs easily... the dynamic contact angle is increased (i.e., wetting is suppressed) when a container formed from a resin containing a cyclic olefin is compared with containers formed from resins widely used
Data Source
AI summary
The first aspect of the present invention relates to an ophthalmic composition comprising (A) one or more kinds selected from the group consisting of terpenoid, a tocopherol, and a benzyl ammonium compound and a salt thereof, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin. The second aspect of the present invention relates to an ophthalmic composition comprising (A2) a surface active component and (B2) a buffer, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.