Cyclic Polyether-Coated Metal Nanoparticles for Salt Tolerance

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Solution Overview

Problem

Conventional metal nanoparticles lack sufficient salt tolerance and stability within a living body, leading to degradation and ineffective performance in applications such as pharmaceutical compositions.

Innovation Solution

A modified metal nanoparticle comprising a metal nanoparticle, typically gold or silver, coated with a cyclic polyether such as cyclic polyethylene oxide, enhancing salt tolerance and heat resistance for use in pharmaceutical compositions like photothermal therapeutic agents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional metal nanoparticles are used, then they can be applied in biosensors and drug delivery, but they lack salt tolerance and degrade in living bodies

Engineering Contradiction:

Improvestability in living bodyVSAvoidsalt tolerance

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

A cyclic polyether (specifically cyclic polyethylene oxide) is introduced as an intermediary substance that coats the surface of metal nanoparticles. This intermediary layer provides salt tolerance and prevents degradation in physiological environments, allowing the nanoparticles to maintain stability in living bodies while retaining their core functions

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention creates a composite structure consisting of a metal nanoparticle core (gold or silver) coated with a cyclic polyether shell. This composite material combines the optical and therapeutic properties of metal nanoparticles with the stability and salt tolerance of cyclic polyether, resolving the contradiction between functionality and environmental stability

Inventive Principle:

Principle #40Composite materials

2Power

If metal nanoparticles are used for photothermal therapy, then therapeutic effect is achieved, but heat resistance is required for effective application

Engineering Contradiction:

Improvephotothermal effectVSAvoidheat resistance

Core Design Contradiction:

PowerVSTemperature

Solution Approach 1:

The cyclic polyether coating acts as a thermal protective intermediary that enables the metal nanoparticle to withstand high temperatures during photothermal therapy. The coating material is selected to maintain structural integrity at elevated temperatures, allowing effective photothermal treatment without particle degradation

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The modified metal nanoparticles demonstrate improved in vivo stability and heat resistance, making them suitable for applications like cancer treatment and MRI contrast agents, with enhanced salt tolerance and photothermal effects.

Implementation Method 1

cyclic polyether modifying the metal nanoparticle... excellent in salt tolerance

Methodology Applied

Scientific EffectElectrostatic repulsion: Electrostatics

Implementation Method 2

cyclic polyether modifying the metal nanoparticle... excellent in salt tolerance

Methodology Applied

Scientific EffectSteric stabilization:

Implementation Method 3

therapeutic agents utilizing a photothermal effect... excellent in heat resistance

Methodology Applied

Scientific EffectPhotothermal conversion:

Data Source

PatentUS11116793B2Modified metal nanoparticle comprising cyclic polyether and pharmaceutical composition

Publication Date: 2021.09.14 HOKKAIDO UNIVERSITY

AI summary

A modified metal nanoparticle comprising a metal nanoparticle and a cyclic polyether modifying the metal nanoparticle.