Cyclic Polyolefin Multilayer Container for Medicament Stability
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Solution Overview
Problem
Current plastic containers for liquid-state medicaments, particularly those containing pyrazolone derivatives like Edaravone, face issues with content reduction due to adhesion, lack of shock resistance, poor handling during filling, and inflexibility, while existing multilayered films are rigid and inadequate for heat-sealing.
Innovation Solution
A multilayered film structure comprising a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer with a resin composition layer, using polypropylene and styrene elastomers, which enhances heat-sealing properties, flexibility, and resistance, and a plastic container molded from this film with specific layer configurations to prevent medicament reduction and ensure sterility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a cyclic polyolefin layer is used to suppress medicament content reduction, then the suppression of medicament adhesion is improved, but the heat-sealing properties and flexibility deteriorate
Solution Approach 1:
The container is divided into multiple functional layers: an inner layer comprising cyclic polyolefin (for suppressing medicament adhesion), an intermediate layer (for heat-sealing properties), and an outer layer (for flexibility and shock resistance). This segmentation allows each layer to specialize in one function, resolving the contradiction between adhesion suppression and heat-sealing capability.
Solution Approach 2:
The patent uses a composite multilayered structure combining cyclic polyolefin with other polymers. The cyclic polyolefin layer provides medicament compatibility, while the intermediate and outer layers provide heat-sealing and mechanical properties. This composite approach allows the system to achieve properties that individual materials cannot provide alone.
2Reliability
If a cyclic polyolefin layer is used to suppress medicament content reduction, then the suppression of medicament adhesion is improved, but the flexibility and shock resistance deteriorate
Solution Approach 1:
The container structure is segmented into functional layers where the cyclic polyolefin inner layer handles medicament compatibility while the outer layers provide mechanical strength and shock resistance. This allows the rigid cyclic polyolefin to be used without compromising overall container flexibility.
Solution Approach 2:
Different regions of the container have different properties tailored to local requirements: the inner surface has cyclic polyolefin for medicament compatibility, while the outer structure has flexible materials for shock absorption. This local optimization resolves the contradiction between adhesion suppression and overall flexibility.
3Reliability
If a multilayered film is made rigid to improve barrier properties, then the suppression of medicament adhesion is improved, but the handling ability and moldability deteriorate
Solution Approach 1:
The multilayered film is segmented into a rigid inner layer (cyclic polyolefin) for barrier properties and softer outer layers for moldability. During manufacturing, the entire multilayered structure can be molded together, with the outer layers providing the necessary flexibility for forming while the inner layer provides the barrier function.
4Reliability
If a multilayered film is made rigid to improve barrier properties, then the suppression of medicament adhesion is improved, but the handling ability during filling deteriorates
Solution Approach 1:
The container is segmented into a rigid cyclic polyolefin inner layer for medicament compatibility and flexible outer layers for handling. The flexible outer layers allow the container to be easily manipulated during filling operations while the inner layer maintains its barrier function.
Solution Approach 2:
The container has local quality variations where the inner surface is rigid and non-adhesive for medicament compatibility, while the outer structure is flexible for easy handling during filling. This local differentiation resolves the contradiction between barrier properties and handling ability.
Data Source
AI summary
The present invention provides and a plastic container and multilayered films, which comprises a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer, wherein the seal layer comprises polypropylene, the cyclic polyolefin layer comprises a cyclic polyolefin polymer or a cyclic polyolefin copolymer, and the outermost layer comprises a layer containing polypropylene, and which further comprises a resin composition layer comprises a blended product of a propylene polymer and a styrene elastomer. The plastic container of the present invention can suppresses a reduction in the medicament content of a liquid-state medicament and is excellent in terms of shock resistance, handling ability during the filling of the container with the medicament, and the moldability and transparency of the container.