Cyclodextrin-Acrylic Microspheres for Sustained Drug Release

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Solution Overview

Problem

Current methods for managing and treating diseases such as cancer and angiogenic-dependent disorders lack effective drug delivery and therapeutic embolization solutions, particularly in terms of targeted and sustained release of therapeutic agents.

Innovation Solution

Development of microspheres composed of biocompatible polymeric materials, including copolymers with acrylic monomers and cyclodextrin derivatives, which can encapsulate therapeutic agents and be designed for controlled release and embolic functions, allowing for both drug delivery and therapeutic embolization.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If conventional drug delivery methods are used, then therapeutic agents can be administered to patients, but the release is not controlled or sustained, leading to ineffective disease management

Engineering Contradiction:

Improveduration of therapeutic agent releaseVSAvoideffectiveness of disease management

Core Design Contradiction:

Duration of action of moving objectVSReliability

Solution Approach 1:

The patent changes the physical and chemical parameters of the drug delivery system by using biocompatible polymeric materials with specific properties (acrylic monomers, cyclodextrin derivatives) that enable controlled release kinetics. The polymer composition and structure are optimized to achieve sustained release over specific time periods, directly addressing the need for both extended duration and reliable therapeutic effect

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention employs composite polymeric materials combining different functional components (acrylic monomers for structural integrity, cyclodextrin derivatives for drug encapsulation and controlled release). This composite approach allows simultaneous achievement of sustained release duration and reliable therapeutic effectiveness by leveraging the complementary properties of each material component

Inventive Principle:

Principle #40Composite materials

2Productivity

If conventional embolization methods are used, then blood flow can be blocked in targeted vessels, but therapeutic agents cannot be effectively delivered to the treatment site

Engineering Contradiction:

Improveefficiency of therapeutic treatmentVSAvoidcomplexity of drug delivery system

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The patent merges two separate therapeutic functions (embolization and drug delivery) into a single integrated microsphere system. The biocompatible polymeric microspheres simultaneously provide mechanical embolic action to block blood flow and serve as carriers for therapeutic agents, achieving both functions through one device rather than requiring separate interventions

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The microsphere system is designed with multi-functionality, serving as both an embolic agent for vascular occlusion and a controlled release vehicle for therapeutic agents. This universal design allows a single product to address multiple therapeutic needs, improving treatment efficiency without significantly increasing system complexity

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Ease of manufacture

If non-biocompatible materials are used for microspheres, then manufacturing may be simpler, but the materials cause adverse reactions in the body

Engineering Contradiction:

Improveease of microsphere productionVSAvoidadverse reactions in the body

Core Design Contradiction:

Ease of manufactureVSObject-affected harmful factors

Solution Approach 1:

The patent selects biocompatible polymeric materials with specific chemical parameters (acrylic monomers, cyclodextrin derivatives) that inherently provide both manufacturability and biocompatibility. The material parameters are chosen to ensure degradation into non-toxic products while maintaining ease of synthesis and processing, thus achieving both ease of manufacture and absence of harmful effects

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The microspheres provide a controlled and sustained release of therapeutic agents, effectively managing and treating diseases by combining drug delivery with embolic effects, thereby improving treatment outcomes for various cancers and angiogenic-dependent disorders.

Implementation Method 1

copolymers with acrylic monomers and cyclodextrin derivatives, which can encapsulate therapeutic agents

Methodology Applied

Scientific EffectInclusion complex formation: Absorption (physical)

Data Source

PatentUS11229604B2Microspheres containing therapeutic agents and related methods of use

Publication Date: 2022.01.25 BIOSPHERE MEDICAL INC

AI summary

Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.