Nutritional Formulation Using Cyclodextrin Complexes for Antioxidant Absorption

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Solution Overview

Problem

Poor nutrition and physical inactivity lead to increased production of free radicals, contributing to health issues like heart disease and cancer, and existing antioxidant formulations do not effectively enhance bioavailability and potency for broad-spectrum protection.

Innovation Solution

A nutritional formulation combining Gac Fruit extract with other antioxidants like Cili Fruit, Siberian Pineapple, and Wolfberry extract, along with cyclodextrin compounds, to enhance absorption and bioavailability of antioxidants, providing a potent and synergistic effect.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional antioxidant supplements are used, then basic antioxidant protection is provided, but absorption and bioavailability are insufficient

Engineering Contradiction:

Improveantioxidant protectionVSAvoidantioxidant absorption

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent employs cyclodextrin compounds as intermediary substances that form inclusion complexes with antioxidant molecules. These cyclodextrin-antioxidant complexes serve as carriers that enhance the absorption and bioavailability of antioxidants, resolving the contradiction between providing antioxidant protection and achieving sufficient absorption. The cyclodextrin acts as a mediator that facilitates the delivery of antioxidants into the body.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates composite material systems by combining cyclodextrin compounds with various antioxidant substances. This composite approach results in enhanced formulations where the synergistic interaction between cyclodextrin and antioxidants produces superior absorption and bioavailability compared to conventional supplements, while maintaining reliable antioxidant protection.

Inventive Principle:

Principle #40Composite materials

2Reliability

If single antioxidant compounds are used, then specific free radical protection is achieved, but broad-spectrum protection is limited

Engineering Contradiction:

Improvefree radical protectionVSAvoidbroad-spectrum protection

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent merges multiple antioxidant compounds into a single formulation, each targeting different free radical types. By combining various antioxidants with different mechanisms of action, the formulation achieves broad-spectrum free radical protection while maintaining reliable protection against specific radicals. This synergistic combination resolves the contradiction between specific and broad protection.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a multi-functional antioxidant system where different antioxidant compounds perform specialized functions against different free radical types. The formulation universally addresses multiple oxidation pathways simultaneously, providing both specific targeted protection and broad-spectrum coverage through the coordinated action of multiple antioxidants.

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Ease of manufacture

If antioxidant formulations are simplified, then manufacturing is easier, but absorption enhancement is reduced

Engineering Contradiction:

Improveformulation simplicityVSAvoidantioxidant bioavailability

Core Design Contradiction:

Ease of manufactureVSQuantity of substance

Solution Approach 1:

The patent introduces cyclodextrin compounds as intermediary substances that, while adding a component to the formulation, actually simplify the overall manufacturing process by providing a standardized mechanism for absorption enhancement. The cyclodextrin-antioxidant complex formation is a well-established process that can be efficiently manufactured, resolving the contradiction between formulation simplicity and absorption enhancement.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The formulation significantly increases antioxidant levels and absorption by up to 40% compared to conventional supplements, offering enhanced protection against free radicals and potential health benefits.

Implementation Method 1

The formulation can include cyclodextrin compounds which have been shown to enhance the absorption and bioavailability of antioxidant compounds

Methodology Applied

Scientific EffectInclusion complex formation:

Implementation Method 2

Antioxidants are free radical scavengers, meaning the anti-oxidant compounds safely interact with free radicals to terminate or reduce the oxidation reaction

Methodology Applied

Scientific EffectFree radical scavenging:

Implementation Method 3

lycopene and beta-carotene are considered some of the most efficient singlet oxygen quenching antioxidants

Methodology Applied

Scientific EffectSinglet oxygen quenching:

Data Source

PatentUS8067045B2Nutritional formulations and associated methods

Publication Date: 2011.11.29 PHARMANEX INC

AI summary

Nutritional formulations and methods for imparting positive health benefits to a subject are disclosed and described. In particular, methods and nutritional formulations for providing increased absorption of antioxidants are taught. In some aspects, the nutritional formulation can include Gac fruit extract in combination with at least one other antioxidant. Such nutritional formulations can in some respects produce enhanced or synergistic results with respect to the amount of antioxidants absorbed by a subject.