Cyclodextrin Antioxidant Composition for Skin Penetration Without Irritation
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Solution Overview
Problem
Existing wound healing and anti-inflammatory compositions face challenges in effectively penetrating the skin to deliver antioxidant ingredients due to skin barrier issues and undesirable side effects from known penetration enhancers.
Innovation Solution
A composition comprising a copper-containing peptide, an antioxidant, and a cyclic oligosaccharide-based polymer, forming a complex, which is formulated to enhance skin penetration and deliver antioxidants effectively.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If skin penetration enhancing compounds are used to deliver antioxidant ingredients, then skin penetration is improved, but skin irritation and toxicity occur
Solution Approach 1:
The patent uses a cyclodextrin derivative as an intermediary carrier molecule that forms an inclusion complex with the antioxidant ingredient. This mediator enables the antioxidant to penetrate the skin barrier without requiring harsh penetration enhancers, thus achieving effective delivery while minimizing skin irritation and toxicity.
Solution Approach 2:
The invention creates a composite delivery system consisting of the antioxidant ingredient encapsulated within a cyclodextrin derivative structure. This composite material combines the therapeutic properties of the antioxidant with the skin-penetrating capabilities of the cyclodextrin carrier, achieving both effective penetration and biocompatibility.
2Productivity
If known penetration enhancers are used to deliver therapeutic agents through skin, then delivery effectiveness is improved, but compatibility with antioxidant compounds deteriorates
Solution Approach 1:
The cyclodextrin derivative serves as a compatible intermediary that works synergistically with antioxidant compounds. Unlike conventional penetration enhancers that may react with or degrade antioxidants, the cyclodextrin carrier provides a stable, biocompatible platform that maintains antioxidant integrity while facilitating skin penetration.
3Productivity
If the skin barrier is made more permeable to deliver therapeutic agents, then drug delivery is improved, but skin protection function deteriorates
Solution Approach 1:
The invention temporarily and locally alters the permeability parameters of the skin barrier at the application site through the cyclodextrin-antioxidant complex, allowing therapeutic delivery. The skin barrier's overall protective function remains intact as the permeability change is localized and reversible, maintaining system reliability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition enhances wound healing and reduces inflammation by penetrating the skin, promoting gene expression of healing-related genes and reducing scar formation, while minimizing side effects.
Implementation Method 1
a cyclic oligosaccharide-based polymer, wherein the copper-containing peptide and the antioxidant form a complex
Data Source
AI summary
Provided herein are compositions that are useful in healing wounds and/or treating inflammatory skin conditions comprising (a) a copper-containing peptide; (b) an antioxidant; and (c) a cyclic oligosaccharide-based polymer, where the copper-containing peptide and the antioxidant form a complex. Further provided herein are methods for healing wounds and/or treating inflammatory skin conditions using the compositions of the disclosure.