Cyclodextrin Aqueous Cannabinoid Extraction for Acid Stability
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Solution Overview
Problem
Current cannabinoid extraction methods from Cannabis sativa L. face challenges such as instability of acid forms, poor solubility in water, and low bioavailability, leading to ineffective and unpleasant oral administration forms.
Innovation Solution
An extraction method using an aqueous solution with at least 40% water and cyclodextrins to form host-guest inclusion complexes with cannabinoids, enhancing solubility and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional extraction methods (oily or alcoholic) are used, then cannabinoids can be extracted from Cannabis sativa L., but the acid forms are unstable and require refrigeration, and oral administration is unpleasant
Solution Approach 1:
Cyclodextrins are used as intermediary molecules that form inclusion complexes with cannabinoids. The cyclodextrin cavity encapsulates the hydrophobic cannabinoid molecules, creating a stable aqueous complex that prevents degradation of acid forms while enabling pleasant oral administration without oil or alcohol carriers
Solution Approach 2:
The invention changes the chemical environment from traditional oily or alcoholic solvents to an aqueous solution containing cyclodextrins. This parameter change in the extraction medium enables stable solubilization of cannabinoids through host-guest complexation, eliminating the need for refrigeration and improving oral acceptability
2Ease of operation
If water is used as extraction solvent, then oral administration becomes pleasant, but cannabinoids have poor solubility in water
Solution Approach 1:
Cyclodextrins act as mediators between the hydrophobic cannabinoids and hydrophilic water. The cyclodextrin molecules have hydrophobic cavities that accommodate cannabinoid molecules while their exterior surfaces are hydrophilic, enabling the formation of stable aqueous solutions with enhanced cannabinoid solubility
Solution Approach 2:
The invention creates a composite extraction system combining water with cyclodextrin molecules. This composite aqueous medium possesses both the hydrophilic properties of water for pleasant oral administration and the hydrophobic binding capacity of cyclodextrins for effective cannabinoid solubilization
3Productivity
If extraction efficiency is improved, then more cannabinoids are obtained, but extraction time increases
Solution Approach 1:
The invention optimizes extraction parameters by using cyclodextrin-concentration gradients and controlled temperature conditions. These parameter changes accelerate the host-guest complexation kinetics, enabling rapid extraction of cannabinoids with high efficiency within reduced timeframes
Solution Approach 2:
The extraction process employs periodic mixing or agitation cycles that enhance mass transfer between the plant matrix and aqueous cyclodextrin solution. This periodic action maintains concentration gradients that drive continuous cannabinoid extraction without requiring prolonged extraction times
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves efficient and rapid extraction of cannabinoids, particularly acid forms, with improved stability and solubility, facilitating effective and pleasant administration.
Implementation Method 1
an extraction step, during which a plant substrate is caused to come into contact with an aqueous liquid... so that at least one cannabinoid is extracted from the plant substrate and carried to the aqueous liquid... The aqueous liquid comprises at least one complexing component, which comprises (in particular, is) at least one cyclodextrin (CD)
Data Source
AI summary
Extraction method comprising an extraction step, during which a plant substrate is caused to come into contact with an aqueous liquid so that cannabinoids are extracted from the plant substrate and carried to the aqueous liquid; the aqueous liquid comprises at least 40% by weight, relative to the total weight of the aqueous liquid, of water and a complexing component; the complexing component is at least one cyclodextrin; the composition obtained is surprisingly stable and the cannabinoids extracted, in particular the acid cannabinoids, which are normally unstable, can be conserved for long periods of time.