Beverage Formulation with Cyclodextrins for Cellular Hydration
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Solution Overview
Problem
Existing compositions and methods fail to effectively enhance cellular hydration and intracellular permeation in multicellular organisms.
Innovation Solution
A beverage composition containing a carbohydrate clathrate component, such as cyclodextrins, in combination with a complex-forming compound, is ingested to form inclusion complexes that temporarily disintegrate membrane lipids and proteins, loosening lipid packing and altering protein structure and function, thereby enhancing intracellular permeation and hydration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional compositions are used, then cellular hydration is maintained at normal levels, but intracellular permeation is insufficient
Solution Approach 1:
The patent changes the physical-chemical parameters of water by adding cyclodextrin clathrates, which alter water structure and properties to enhance both hydration and permeation simultaneously
Solution Approach 2:
Cyclodextrin clathrates act as intermediary substances that mediate between water and cell membranes, facilitating enhanced permeation while maintaining hydration
2Productivity
If membrane structure is disrupted to enhance permeation, then intracellular transport improves, but membrane stability decreases
Solution Approach 1:
The patent employs dynamic disruption of membrane structure through cyclodextrin clathrates that temporarily loosen lipid packing and alter protein structure to enhance permeation, while the membrane returns to its stable state after the action subsides
Solution Approach 2:
The membrane disruption occurs in periodic cycles where cyclodextrin clathrates temporarily alter membrane structure to enhance permeation, followed by restoration of membrane stability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition increases cellular hydration and intracellular permeation, promoting nutrient and water transport, and can extend lifespan in multicellular organisms like C. elegans and potentially humans.
Implementation Method 1
Water molecules interact principally through hydrogen (H)-bonding and through alignment of dipole moments
Implementation Method 2
a primary carbohydrate clathrate subcomponent that increases the H-bonded structure of water
Implementation Method 3
enhancing intracellular permeation and hydration
Data Source
AI summary
A method of promoting increased cellular hydration in a multicellular organism that is capable of intracellular water permeation includes the step of causing the multicellular organism to ingest an aqueous solution that contains an amount of a carbohydrate clathrate component. There is also a step of enhancing the intracellular permeation. The multicellular organism contains aquaporins, and the causing step involves interaction of the composition with the aquaporins. The cellular hydration promoted and caused by the method is corroborated by a test that uses human-aquaporin-expressed frog oocytes. The test uses single cell Xenopus laevis frog oocytes having expressed human aquaporin AGP1 water channels. There is also a beverage composition that increases lifespan in the multicellular organism, and a beverage composition that promotes cellular hydration when ingested by a multicellular organism.