Cyclodextrin-Trapped Copper Peptide Composition for Wound Healing
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Solution Overview
Problem
Existing wound healing and anti-inflammatory compositions face challenges in effectively penetrating the skin and delivering antioxidants due to skin irritation and toxicity issues, limiting their efficacy in suppressing inflammatory molecule expression.
Innovation Solution
A composition comprising a copper-containing peptide, an antioxidant, and a cyclic oligosaccharide-based polymer, forming a complex, which is entrapped by the polymer, to enhance skin penetration and deliver antioxidants.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If skin penetration enhancing compounds are used to deliver antioxidants, then skin penetration is improved, but skin irritation and toxicity increase
Solution Approach 1:
The patent uses cyclodextrin as an intermediary carrier molecule that forms inclusion complexes with antioxidants. This mediator enables safe skin penetration by protecting the antioxidant from direct contact with skin tissues while facilitating transport through the skin barrier, thus achieving penetration enhancement without the associated irritation and toxicity problems
Solution Approach 2:
The patent creates a composite delivery system consisting of cyclodextrin-antioxidant complexes combined with copper-containing peptides. This composite material leverages the penetration-enhancing properties of the peptide while the cyclodextrin carrier ensures safe delivery of the antioxidant, achieving both effective penetration and biocompatibility
2Reliability
If conventional antioxidants are applied topically, then anti-oxidant activity is achieved, but skin penetration is insufficient to reach inflammatory molecules
Solution Approach 1:
The patent employs the nested structure of cyclodextrin molecules where the hydrophobic cavity of the cyclodextrin ring accommodates the antioxidant molecule. This nesting arrangement protects the antioxidant during transit and enables deep skin penetration while maintaining the antioxidant's activity once delivered to the target site
3Reliability
If high concentrations of antioxidants are used to ensure efficacy, then anti-inflammatory effect is improved, but skin irritation increases
Solution Approach 1:
The cyclodextrin carrier acts as a mediator that enables the use of higher antioxidant concentrations by controlling their release and distribution. The inclusion complex prevents direct irritation while ensuring sufficient antioxidant delivery to inflammatory sites, thereby maintaining efficacy without proportionally increasing irritation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively penetrates the skin, delivering antioxidants to suppress inflammatory molecule expression, promoting wound healing and reducing inflammation, while minimizing skin irritation and toxicity.
Implementation Method 1
a copper-containing peptide and an antioxidant form a complex
Implementation Method 2
the complex formed by the copper-containing peptide and the antioxidant is entrapped by the cyclic oligosaccharide-based polymer
Data Source
AI summary
Provided herein are compositions that are useful in healing wounds and/or treating inflammatory skin conditions comprising (a) a copper-containing peptide; (b) an antioxidant; and (c) a cyclic oligosaccharide-based polymer, where the copper-containing peptide and the antioxidant form a complex. Further provided herein are methods for healing wounds and/or treating inflammatory skin conditions using the compositions of the disclosure.