Cyclodextrin Inclusion for Non-Psychoactive Cannabinoid Purification
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Solution Overview
Problem
Current methods for preparing inclusion compounds containing non-psychoactive cannabinoids fail to simultaneously remove psychoactive cannabinoids like THC, THCV, and CBN, limiting the development and application of cannabinoid drugs.
Innovation Solution
A method involving a cannabis extract and an inclusion agent, such as cyclodextrin, is used to create an inclusion compound where the weight ratio of the inclusion agent to cannabis extract is optimized, allowing for the selective inclusion of non-psychoactive cannabinoids like CBD, CBDV, and CBG, while minimizing psychoactive cannabinoids to less than 0.01% content, through a process involving solution mixing, precipitation, and vacuum drying.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional separation and purification methods (chromatography, macroporous adsorption resin) are used to remove THC, then THC removal is achieved, but psychoactive cannabinoids like THCV and CBN cannot be removed simultaneously
Solution Approach 1:
The patent changes the separation parameter from conventional chromatography methods to inclusion compound formation based on molecular cavity recognition. By selecting inclusion agents with specific cavity structures (such as cyclodextrins with different ring sizes), the method achieves selective inclusion of non-psychoactive cannabinoids while excluding psychoactive cannabinoids like THC, THCV, and CBN, thereby simultaneously removing multiple psychoactive components and achieving high purity
Solution Approach 2:
The patent introduces inclusion agents (host molecules) as intermediaries to facilitate the separation process. These inclusion agents form inclusion compounds specifically with non-psychoactive cannabinoids through host-guest molecular recognition, enabling selective enrichment and purification while leaving psychoactive cannabinoids in the mother liquor for removal, thus achieving comprehensive purification that conventional methods cannot accomplish
2Quantity of substance
If only THC removal is achieved while retaining other psychoactive cannabinoids, then the effective ingredient retention is improved, but the safety and application scope are limited
Solution Approach 1:
The patent employs parameter changes in the form of selecting different inclusion agents with varying cavity structures and binding affinities. By optimizing the inclusion agent type and the inclusion process parameters (such as solvent system, temperature, and concentration ratios), the method achieves selective inclusion of non-psychoactive cannabinoids while excluding psychoactive cannabinoids, thereby ensuring both high effective ingredient retention and elimination of harmful psychoactive components
Solution Approach 2:
The patent applies the extraction principle by using inclusion agents to selectively extract and encapsulate non-psychoactive cannabinoids from the cannabis extract. The inclusion agents form stable inclusion compounds with the desired non-psychoactive cannabinoids, separating them from psychoactive cannabinoids that remain in the solution, thus achieving purification that simultaneously retains effective ingredients and removes harmful substances
3Productivity
If conventional extraction and purification methods are used, then the extraction efficiency is maintained, but the stability of non-psychoactive cannabinoids during processing is reduced
Solution Approach 1:
The patent applies preliminary action by forming inclusion compounds with non-psychoactive cannabinoids early in the processing sequence, before subsequent purification and concentration steps. The inclusion agents protect the non-psychoactive cannabinoids from oxidation and degradation during these processing steps, maintaining their stability while allowing efficient extraction and purification to proceed
Solution Approach 2:
The inclusion agents serve as protective intermediaries that encapsulate non-psychoactive cannabinoids, shielding them from environmental factors that cause degradation (such as oxygen, light, and heat) during the extraction and purification process. This protective encapsulation maintains the stability and integrity of the non-psychoactive cannabinoids throughout processing while allowing efficient separation and concentration
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method effectively enriches and purifies non-psychoactive cannabinoids, improving their stability and allowing for their extensive retention, making them suitable for further pharmaceutical preparations without the presence of psychoactive compounds.
Implementation Method 1
The complex is a combination of drug molecules and inclusion material molecules through van der Waals forces
Implementation Method 2
Inclusion compound refers to a special complex formed by completely or partially encapsulating a molecule in the cavity structure of another molecule
Data Source
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AI summary
Disclosed are an inclusion compound containing a non-psychoactive cannabinoid, and a method for preparation thereof. The inclusion compound is prepared by means of the following method: a cannabis extract is subjected to, in sequence, dissolving in organic solvent, incorporation of inclusion agent, analysis and removal of impurities in water-organic solvent, and vacuum drying and precipitation, and thus obtained. In the inclusion compound, psychoactive ingredients such as tetrahydrocannabidiol (THC) and Δ9-tetrahydrocannabinol (THCV) may be completely removed, effectively enriching the non-psychoactive ingredients such as cannabidiol (CBD), cannabigerol (CBG), cannabichromene (CBC), and so on with a total content of greater than 50%. The processing technique of the preparation method is simple to perform, and is conducive to commercialization.