Cyclodextrin Isolation via Metal-Organic Framework Complexes
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Solution Overview
Problem
Conventional methods for isolating cyclodextrins (CDs) are time-consuming and costly, particularly for large-scale production, and often require difficult and costly removal of organic agents from CD complexes, with no economical solvent recovery process available.
Innovation Solution
Forming CD-MOF complexes by contacting a CD production mixture with a metal salt, using non-toxic solvents like ethanol for efficient isolation of αCD and γCD, which can be easily removed by evaporation, and employing methods such as filtration, centrifugation, and ion exchange to separate and purify the CDs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If conventional methods using organic agents are used to isolate CDs, then CDs can be complexed and isolated, but the organic agents are difficult and time-consuming to remove from the CD cavity
Solution Approach 1:
The patent changes the type of solvent from conventional organic agents (cyclododecanone, cyclohexadec-8-en-1-one) to alcohols (methanol, ethanol, propanol). This parameter change in solvent chemistry enables easier removal through evaporation without requiring complex distillation or extraction processes, directly resolving the time-consuming solvent removal problem.
Solution Approach 2:
The patent utilizes the phase transition properties of alcohol solvents, which can be easily evaporated at relatively low temperatures compared to conventional organic agents. The alcohol solvent forms a complex with the CD, then undergoes phase transition from liquid to vapor through simple evaporation, leaving the CD isolated without requiring energy-intensive distillation or liquid-liquid extraction.
2Productivity
If conventional methods are used for large-scale CD production, then CDs can be produced, but the process is costly and time-consuming with no economical solvent recovery process
Solution Approach 1:
The patent changes the solvent parameter to alcohols that have favorable evaporation characteristics for large-scale processing. This enables economical solvent recovery through simple evaporation and condensation processes, making large-scale CD production both faster and more cost-effective compared to conventional methods requiring complex solvent recovery systems.
3Ease of manufacture
If conventional organic agents are used to complex with CDs, then CDs can be isolated, but the solvents are difficult to remove and require steam distillation or liquid-liquid extraction
Solution Approach 1:
The patent changes the solvent parameter from heavy organic agents to lighter alcohols with lower boiling points and higher volatility. This enables solvent removal through simple evaporation without requiring complex equipment such as steam distillation apparatus or liquid-liquid extraction systems, directly reducing device complexity.
4Productivity
If conventional methods are used for CD isolation, then CDs can be produced, but the process requires difficult and costly solvent recovery for reuse
Solution Approach 1:
The patent utilizes the phase transition of alcohol solvents from liquid to vapor through evaporation, then back to liquid through condensation. This simple phase transition process enables economical solvent recovery and reuse, eliminating the need for costly and complex solvent recovery systems required by conventional methods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method significantly reduces time and cost for isolating CDs, enabling large-scale commercial production while using safe solvents suitable for pharmaceutical or food applications, and allows for easy removal of solvents, improving the efficiency and scalability of CD isolation.
Implementation Method 1
forming CD-MOF complexes. The CD production mixture contains αCD, βCD, γCD, and CD production byproducts. The CD-MOF complexes include αCD-MOF and γCD-MOF complexes and each CD-MOF complex contains at least a metal cation and a plurality of CD components
Implementation Method 2
For example, ethanol can be used to form and isolate CD-MOF complexes, and any trace amounts of ethanol can be readily removed by evaporation
Implementation Method 3
employing methods such as filtration, centrifugation, and ion exchange to separate and purify the CDs
Implementation Method 4
employing methods such as filtration, centrifugation, and ion exchange to separate and purify the CDs
Implementation Method 5
employing methods such as filtration, centrifugation, and ion exchange to separate and purify the CDs
Data Source
AI summary
This disclosure relates to methods of isolating CDs. The method includes contacting a CD production mixture containing αCD, βCD, γCD, and CD production byproducts with a metal salt; and forming CD-MOF complexes containing at least a metal cation and a plurality of CD components.