Cyclodextrin Metal-Organic Framework Rapid Synthesis
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Solution Overview
Problem
The long synthesis time of cyclodextrin-based metal-organic frameworks (CD-MOFs) hinders their large-scale industrial production due to harsh conditions and biotoxicity of traditional methods, limiting their application in biological and medicinal fields.
Innovation Solution
A method involving the formulation of a supersaturated γ-CD alkaline alcohol solution, heating, and controlled cooling to induce rapid crystallization and separation of CD-MOFs, reducing synthesis time from hours to minutes while maintaining biodegradability and high specific surface area.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional self-assembly method is used to prepare CD-MOFs, then good biocompatibility and biodegradability are achieved, but synthesis time is too long (dozens of hours)
Solution Approach 1:
The patent prepares a supersaturated γ-CD alkaline alcohol solution in advance before the actual crystallization process. This preliminary preparation of the supersaturated solution enables the rapid crystallization to proceed much faster than traditional methods, reducing synthesis time from dozens of hours to just a few hours while maintaining the biocompatibility of the final CD-MOFs product
Solution Approach 2:
The patent changes key parameters including using alkaline conditions (pH 12-14), supersaturated solution concentration, and alcohol-water mixed solvent system. These parameter changes create optimal conditions for rapid crystallization while preserving the biodegradability and biocompatibility characteristics of cyclodextrin-based materials
2Manufacturing precision
If traditional synthesis conditions are used, then CD-MOFs with good crystallization are obtained, but harsh conditions (high temperature, organic solvents) are required
Solution Approach 1:
The patent uses mild alkaline conditions (pH 12-14) instead of strongly acidic or oxidizing conditions, and employs an alcohol-water mixed solvent system that is less harsh than traditional pure organic solvents. These parameter changes enable good crystallization quality while reducing the harmful effects of harsh synthesis conditions
Solution Approach 2:
The patent uses readily available, inexpensive materials such as γ-cyclodextrin, common alcohols (methanol or ethanol), and alkali metal ions. These materials are biodegradable and environmentally friendly, replacing expensive or persistent organic ligands while achieving good crystallization quality
3Reliability
If traditional synthesis method is used, then CD-MOFs are prepared, but scale production is limited due to long reaction time
Solution Approach 1:
The preparation of supersaturated γ-CD alkaline alcohol solution before crystallization acts as a preliminary action that dramatically accelerates the overall process. This enables scale production by reducing the time bottleneck while maintaining the biodegradability of the CD-MOFs product through the use of cyclodextrin and biodegradable alkali metal ions
Solution Approach 2:
The patent establishes a continuous process where the supersaturated solution is prepared and then immediately used for crystallization upon cooling. This continuous workflow eliminates idle time between steps, improving productivity for scale production while maintaining the environmentally friendly and biodegradable characteristics of the materials used
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method enables rapid, efficient, and environmentally friendly production of CD-MOFs with perfect crystallization and large specific surface area, suitable for industrial-scale production and broader applications, including biological and medicinal uses.
Implementation Method 1
inducing the γ-CD dissolution and crystallization behavior in solution via simply heating and cooling the γ-CD supersaturated alkaline alcoholic solution
Implementation Method 2
inducing dissolution and crystallization behaviors of the γ-CD in the alcohol solution via simply controlling heating and cooling processes
Implementation Method 3
heating to obtain a hot γ-CD solution; and cooling the hot γ-CD solution of the step (2), and performing crystallization and separation to obtain the CD-MOFs
Implementation Method 4
heating to obtain a hot γ-CD solution
Implementation Method 5
cooling the hot γ-CD solution of the step (2), and performing crystallization and separation to obtain the CD-MOFs
Data Source
AI summary
The present disclosure belongs to the field of chemical industry production, and particularly relates to CD-MOFs and a preparation method thereof. The preparation method comprises the following steps: (1) formulating a supersaturated γ-cyclodextrin alkaline alcohol aqueous solution containing an alkali metal ion; (2) heating to obtain a hot γ-cyclodextrin solution; and (3) cooling the hot γ-cyclodextrin solution of the step (2), and performing crystallization and separation to obtain the cyclodextrin-based metal organic framework material. The CD-MOFs has perfect crystallization and large specific surface area, which are similar with those of a material prepared by means of traditional methods. The important thing is that the synthesis operation thereof is simple, green, and environmentally friendly, and the time required is shortened from a few hours or even tens of hours to a few minutes, which significantly improves the synthesis efficiency and is conductive to industrial scale production.