Cyclohexane-Based Glycomimetics for Endothelial Dysfunction

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Solution Overview

Problem

The high cost and complexity of producing monosaccharides and oligosaccharides, particularly when mass production is required, and the need for effective treatments for endothelial dysfunction and related diseases such as diabetes, where existing glycomimetics do not significantly reduce production costs.

Innovation Solution

Development of oligosaccharide mimic compounds incorporating cyclohexane derivatives, which are administered to treat endothelial dysfunction and other conditions, including diabetes, by attaching cyclohexane derivatives to oligosaccharides or glycomimetics, potentially reducing production costs and improving biological efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If monosaccharides and oligosaccharides are mass produced, then the quantity of substance increases, but the production cost and complexity increase significantly

Engineering Contradiction:

Improveproduction quantityVSAvoidproduction cost and complexity

Core Design Contradiction:

Quantity of substanceVSEase of manufacture

Solution Approach 1:

The patent creates simplified copies of monosaccharides and oligosaccharides by replacing complex sugar structures with cyclohexane derivatives that mimic the biological functionality. This copying approach allows mass production at lower cost while maintaining therapeutic efficacy for endothelial dysfunction and diabetes treatment

Inventive Principle:

Principle #26Copying

Solution Approach 2:

The patent changes the chemical structure parameters by substituting oxygen atoms in the sugar ring with carbon atoms, creating cyclohexane-based mimics. This parameter change simplifies the molecular structure, reducing production complexity and cost while preserving the essential biological recognition and therapeutic effects

Inventive Principle:

Principle #35Parameter changes

2Reliability

If existing glycomimetics are used to treat endothelial dysfunction, then treatment efficacy is achieved, but production cost remains high

Engineering Contradiction:

Improvetreatment efficacyVSAvoidproduction cost

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent develops inexpensive cyclohexane-based glycomimetics that can be produced at low cost for therapeutic use. These simplified structures serve as effective, affordable alternatives to expensive natural oligosaccharides for treating endothelial dysfunction and diabetes, making widespread clinical application economically feasible

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Ease of manufacture

If cyclohexane derivatives are incorporated into oligosaccharide mimics, then production cost and complexity are reduced, but structural complexity of the molecule increases

Engineering Contradiction:

Improveproduction cost and complexityVSAvoidmolecular structure complexity

Core Design Contradiction:

Ease of manufactureVSDevice complexity

Solution Approach 1:

The patent extracts the essential functional features of monosaccharides and oligosaccharides (cyclic structure, hydroxyl groups, biological recognition capability) and isolates them from the complex natural sugar structures. By taking out only the critical functional elements and implementing them on simple cyclohexane cores, the patent reduces production complexity while maintaining therapeutic efficacy

Inventive Principle:

Principle #2Taking out (Extraction)

Data Source

PatentUS8026222B2Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines

Publication Date: 2011.09.27 GLYCOMIMETICS INC

AI summary

Methods are provided for using a compound to treat, for example, endothelial dysfunction including vascular abnormalities. More specifically, methods are described for using an oligosaccharide compound or glycomimetic compound wherein a cyclohexane derivative is incorporated in either.