Cyclohexanol Derivatives Antimicrobial Formulation Compatibility
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current antimicrobial compounds used in cosmetics and other applications face challenges in compatibility, formulatability, and effectiveness against microorganisms such as bacteria and fungi, particularly in maintaining skin health and preventing conditions like acne and dandruff, while also addressing odor issues.
Innovation Solution
The use of cyclohexanol derivatives with specific radical configurations, which exhibit excellent antimicrobial activity against a range of microorganisms, including Staphylococcus and Malassezia species, and have properties suitable for incorporation into various formulations as antimicrobial, anti-acne, antidandruff, and antiperspirant agents, enhancing skin health and odor control.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antimicrobial compounds are used, then microbial contamination is controlled, but compatibility and formulatability in cosmetic products deteriorate
Solution Approach 1:
The patent modifies the chemical structure of antimicrobial compounds by introducing specific radical groups (R1-R7) with varying chain lengths and configurations. This parameter change in molecular structure maintains antimicrobial effectiveness while improving compatibility with cosmetic formulations, allowing the compounds to function effectively across different product types.
Solution Approach 2:
The invention creates composite molecular structures combining cyclohexane rings with various radical groups (alkyl, alkoxy, hydroxyl, carboxyl). These composite structures integrate the antimicrobial properties of the core structure with the formulation compatibility of the attached radicals, resolving the contradiction between effectiveness and formulatability.
2Reliability
If antimicrobial substances are used to control bacteria, then microbial growth is inhibited, but compatibility with skin and cosmetic ingredients deteriorates
Solution Approach 1:
The patent applies local quality by attaching different functional radicals to specific positions on the cyclohexane ring structure. Each radical configuration (R1-R7) provides localized functionality that balances antimicrobial activity with skin compatibility, allowing the molecule to exert its antimicrobial effect while maintaining gentleness toward skin tissues.
Solution Approach 2:
By systematically varying the parameters of the radical groups (chain length, saturation, functional groups), the patent optimizes the balance between antimicrobial potency and skin compatibility. Specific configurations like saturated vs. unsaturated radicals provide different levels of skin friendliness while maintaining antimicrobial effectiveness.
3Adaptability or versatility
If liquid state ingredients are used at room temperature, then formulatability is improved, but antimicrobial effectiveness may deteriorate
Solution Approach 1:
The patent achieves the dual goal by carefully controlling the chain length and saturation of the radical groups attached to the cyclohexane core. These parameter changes directly influence both the melting point (affecting physical state) and the antimicrobial activity, allowing optimization of both formulatability and effectiveness simultaneously.
Data Source
AI summary
The present invention relates to the use of at least one cyclohexanol derivative of the formula (I) and/or (II) as antimicrobial active compound or as anti-acne, antidandruff, antiperspirant or deodorant active compound, to preparations comprising these compounds, and to specific cyclohexanol derivatives and to a process for the preparation thereof.