Cycloketene Acetal Bone Adhesive via Ring-Opening Polymerization
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Solution Overview
Problem
Traditional medical adhesives, such as cyanoacrylate, face issues with high hardness, poor toughness, toxicity, and refractory degradation, which hinder tissue healing and limit their application in bone adhesion due to lack of biodegradability and osteogenic activity.
Innovation Solution
A fast-curing and degradable strong bone adhesive is developed, comprising a cycloketene acetal compound and a vinyl monomer mixture with a cross-linking agent and reducing agent, which undergoes in-situ free radical ring-opening polymerization, forming a structure with ester bonds for biodegradability and osteogenic activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If traditional cyanoacrylate medical adhesive is used, then fast curing and good instant adhesion strength are achieved, but the polymer product becomes hard and brittle, releasing toxic substances and being difficult to degrade
Solution Approach 1:
The patent changes the chemical parameters of the adhesive by replacing cyanoacrylate with cycloketene acetal compounds, fundamentally altering the polymerization mechanism and degradation properties while maintaining fast curing characteristics
Solution Approach 2:
The patent creates a composite system by combining cycloketene acetal compound with vinyl monomer, cross-linking agent, and bioactive particles, achieving both fast curing and biodegradability through material composition optimization
2Strength
If formaldehyde inhibitor is added to cyanoacrylate medical adhesive, then toughness of adhesive film is improved, but refractory degradation problem still exists
Solution Approach 1:
The patent fundamentally changes the chemical structure from cyanoacrylate to cycloketene acetal, which inherently provides both improved toughness and biodegradability through the ester bond-containing polymer backbone
Solution Approach 2:
The patent extracts and eliminates the refractory degradation property by removing the cyanoacrylate chemical structure and replacing it with biodegradable cycloketene acetal-based polymer structure
3Duration of action of stationary object
If natural polymer such as gelatin-based hydrogel is introduced to improve degradability, then biodegradability is achieved, but adhesion and mechanical strength become far less than synthetic adhesives
Solution Approach 1:
The patent creates a composite material system combining synthetic cycloketene acetal-based polymer with controlled biodegradability, achieving both high mechanical strength and biodegradability that neither pure natural nor pure synthetic materials can achieve alone
Solution Approach 2:
The patent introduces local biodegradability through ester bonds in the polymer backbone while maintaining overall structural integrity and mechanical strength through cross-linking and bioactive particle reinforcement
4Strength
If traditional medical adhesive is used for bone adhesion, then adhesion is achieved, but lack of osteogenic activity hinders bone tissue regeneration
Solution Approach 1:
The patent makes the adhesive multi-functional by incorporating bioactive particles that provide osteogenic activity, transforming it from a simple adhesive into a composite material that simultaneously adheres bone tissue and promotes regeneration
Solution Approach 2:
The patent introduces bioactive particles as intermediary substances that mediate between the adhesive and bone tissue, facilitating osteogenic activity and tissue regeneration while the adhesive provides mechanical bonding
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive achieves rapid adhesion, high mechanical strength, and biodegradability, promoting bone tissue regeneration while avoiding tissue damage and infection, with a simple preparation method and clinical maneuverability.
Implementation Method 1
undergoes in-situ free radical ring-opening polymerization, forming a structure with ester bonds for biodegradability and osteogenic activity
Implementation Method 2
The component A comprises a cycloketene acetal compound and an oxidizing agent; The component B comprises a vinyl monomer, a cross-linking agent and a reducing agent
Data Source
AI summary
The present disclosure provides a medical adhesive and a preparation method thereof, comprising a component A and a component B: the component A comprises a cycloketene acetal compound and an oxidizing agent; the component B comprises a vinyl monomer, a cross-linking agent and a reducing agent, wherein the cycloketene acetal compound is selected from one or more of 2-methylene-1,3-dioxepane, 2-methylene-4-phenyl-1,3-dioxolane, 5,6-benzo-2-methylene-1,3-dioxepane and 4,7-dimethyl-2-methylene-1,3-dioxepane. The medical adhesive overcomes the disadvantages of conventional medical adhesives.