Cyclopropanecarbonitrile Fragrance Synthesis via Segmentation
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Solution Overview
Problem
The fragrance industry faces a continuous need for new chemical entities to create diverse and innovative perfumes and personal care products, as variations in chemical structure significantly impact odor and characteristics, necessitating the discovery of new compounds.
Innovation Solution
The development and use of novel compounds, specifically (2,6,6-Trimethyl-1-cylohexen-1-yl)-cyclopropanecarbonitrile and 2-(2,6,6-Trimethyl-2-cylohexen-1-yl)-cyclopropanecarbonitrile, which are synthesized through a Corey's cyclopropanation reaction and provide unique fragrance notes such as vetiver, citrus, and woody scents, suitable for enhancing perfumes and personal care products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If new chemical compounds are synthesized to create diverse fragrances, then the variety and innovation of perfume characteristics are improved, but the complexity of chemical structure analysis and synthesis increases
Solution Approach 1:
The patent segments the fragrance molecule into a standardized cyclopropanecarbonitrile core structure with variable substituent groups. This modular approach allows systematic variation of fragrance characteristics by changing only the substituent while maintaining the core structure, thereby increasing fragrance variety without proportionally increasing overall molecular complexity.
Solution Approach 2:
The patent systematically varies chemical parameters such as substituent groups (R1, R2, R3, R4), ring saturation, and stereochemistry of the cyclopropanecarbonitrile core to generate diverse fragrance profiles. By changing these parameters in a controlled manner, new fragrance characteristics are achieved while maintaining synthesis feasibility through established chemical transformations.
2Adaptability or versatility
If novel compounds with unique olfactory characteristics are developed, then the创新能力 of perfume compositions is improved, but the difficulty of synthesis and manufacturing increases
Solution Approach 1:
The patent identifies a universal cyclopropanecarbonitrile core structure that serves as a platform for multiple fragrance variants. This core can be synthesized once and then diversified through various substitution reactions, allowing multiple unique olfactory characteristics to be derived from a single synthetic route, thereby reducing overall manufacturing difficulty.
Solution Approach 2:
The patent performs preliminary synthesis of the cyclopropanecarbonitrile core structure and its derivatives before final fragrance formulation. By preparing these intermediate compounds in advance with controlled purity and characterization, the subsequent fragrance blending and formulation processes are simplified, reducing the overall synthesis and manufacturing difficulty.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These compounds effectively enhance the fragrance of perfumes and personal care products by offering distinct olfactory characteristics, allowing for the creation of new and complex scents, applicable in a wide range of products from soaps to air fresheners, with adjustable concentrations to achieve desired aroma intensities.
Implementation Method 1
The compounds of the present invention may be prepared from the corresponding compounds via a Corey's cyclopropanation reaction of the following sequence
Data Source
AI summary
The present invention is directed to the novel cyclopropanated cyclohexyl ester compounds of the general formula: