Cyperus Rotundus Microbubble Extract for Skin Barrier and Inflammation
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Solution Overview
Problem
Existing extraction methods for Cyperus rotundus do not effectively harness its anti-inflammatory, skin-soothing, and skin barrier-enhancing properties, limiting the efficacy of cosmetic and pharmaceutical compositions.
Innovation Solution
A microbubble extraction method using warm microbubbles with specific conditions (5 to 50 μm pore size, 1.0 to 1.2 Ton/hr discharge rate, 40° C. to 60° C. temperature, and 3 to 4 bar pressure) to extract Cyperus rotundus, enhancing the extract's anti-inflammatory and skin-soothing effects by inhibiting inflammatory gene expression and improving skin barrier genes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If static extraction method using existing solvent is used, then extraction process is simple, but extraction efficacy of active ingredients is insufficient
Solution Approach 1:
The patent replaces the conventional static chemical extraction method with a dynamic mechanical extraction method using microbubbles. The microbubble generation device creates vigorous bubbling action that mechanically disrupts plant cells and enhances solvent penetration, substituting the passive diffusion-based static extraction with an active mechanical mixing and cavitation process, thereby significantly improving extraction efficacy while maintaining operational simplicity
Solution Approach 2:
The patent changes the physical parameters of the extraction system by introducing microbubbles with specific size distribution (5-50 μm) and controlling gas flow rate (3-4 L/min) and pressure (3-4 bar). These parameter changes create intense micro-turbulence and cavitation effects that dramatically enhance the extraction of active ingredients from Cyperus rotundus, transforming the extraction efficiency without complicating the overall process
2Productivity
If microbubble extraction method is used, then extraction efficacy is improved, but extraction process complexity increases
Solution Approach 1:
The patent segments the extraction process into distinct functional modules: a microbubble generation device with specific pore size (5-50 μm) that separates bubble generation from the extraction chamber, and a controlled gas supply system. This segmentation allows the complex microbubble generation function to be isolated in a dedicated device while keeping the main extraction process simple and manageable
Solution Approach 2:
The patent introduces an intermediary gas phase (air or oxygen) that serves as a mediator between the energy input system and the extraction solvent. The gas forms microbubbles that act as intermediaries, transferring mechanical energy and enhancing mass transfer between the solvent and plant material without requiring direct mechanical contact or complex mixing mechanisms, thus simplifying the overall system
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The extract inhibits nitric oxide production, reduces inflammatory gene expression, enhances skin barrier genes, and improves skin moisture, providing effective skin soothing and irritation relief.
Implementation Method 1
Microbubbles are used in various fields by applying sterilization and cleaning functions using physicochemical properties, such as gas dissolution effect
Implementation Method 2
oxidation-reduction action of micro-sized bubbles
Implementation Method 3
the extract is characterized by inhibiting nitric oxide (NO) production. In addition, the extract has an efficacy of inhibiting the expression of a gene selected from the group consisting of interleukin 6 (IL-6), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), which are inflammatory expression factors
Implementation Method 4
the extract may have an efficacy of enhancing the skin barrier. In addition, the extract may have a moisturizing efficacy by preventing transepidermal water loss and increasing skin moisture content
Data Source
AI summary
The present disclosure relates to a cosmetic composition containing an extract of Cyperus rotundus extracted using warm microbubbles. The extract inhibits nitric oxide (NO) production and exhibits excellent anti-inflammatory efficacy by inhibiting the expression of interleukin 6 (IL-6), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), which are inflammatory expression factors. In addition, the extract enhances the expression of aquaporin-3 (AQP-3), hyaluronan synthase 2 (HAS-2), claudin-1 (CLDN-1), cadherin 1 (CDH1), filaggrin (FLG), and involucrin (IVL), which are genes related to the skin barrier and moisturizing. Thus, when using the extract for cosmetic products, excellent effects can be exhibited in skin soothing, moisturizing, enhancement of the skin barrier, relief of irritation such as erythema, relief of pruritus, and the like, so the extract can be usefully applied to multi-care products that improve skin conditions.