Cyphenothrin Composition for Flea Biting Prevention

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Solution Overview

Problem

Current flea control methods, such as those using fipronil, imidacloprid, metaflumizone, mitenpyram, and spinosad, are ineffective in completely preventing flea bites and blood feeding, leading to ongoing flea allergy dermatitis in dogs and cats, as they primarily reduce flea feeding over time rather than eliminating biting.

Innovation Solution

A composition comprising up to 50% cyphenothrin and 50% to 85% organic solvent, administered topically, which prevents fleas from taking a blood meal by repelling them before they die, thereby significantly reducing the incidence of flea allergy dermatitis in companion animals.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If conventional flea control compounds (fipronil, imidacloprid, metaflumizone, mitenpyram, spinosad) are used, then flea feeding is reduced over prolonged period, but flea biting is not sufficiently prevented

Engineering Contradiction:

Improveprolonged period flea feeding reductionVSAvoidprevention of flea biting

Core Design Contradiction:

Duration of action of moving objectVSReliability

Solution Approach 1:

The patent changes the chemical parameter by using cyphenothrin, a pyrethroid compound with different mode of action and faster kill kinetics compared to conventional compounds. This parameter change enables immediate prevention of flea biting while maintaining prolonged feeding reduction efficacy

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent replaces the gradual action mechanism of conventional flea control compounds with a rapid neurotoxic mechanism characteristic of pyrethroids. This substitution enables immediate flea killing upon contact, preventing biting before it occurs, while the prolonged residual activity maintains feeding reduction over time

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Quantity of substance

If conventional flea control compounds are used, then egg production is reduced, but flea bites and blood feeding are not sufficiently stopped

Engineering Contradiction:

Improveegg production reductionVSAvoidflea bites and blood feeding

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent applies preliminary action by killing fleas immediately upon contact with cyphenothrin, preventing them from taking blood meals or laying eggs. This preemptive killing occurs before the fleas can complete their harmful functions, addressing both blood feeding prevention and egg production reduction simultaneously

Inventive Principle:

Principle #10Preliminary action

3Quantity of substance

If flea control treatment is applied, then flea population is reduced, but flea allergy dermatitis incidence is not sufficiently prevented

Engineering Contradiction:

Improveflea population reductionVSAvoidflea allergy dermatitis incidence

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent applies preliminary anti-action by preventing flea bites through immediate killing action of cyphenothrin. This preliminary prevention stops the causal chain before flea saliva can trigger the allergic reaction, thereby preventing flea allergy dermatitis incidence even when some fleas remain in the environment

Inventive Principle:

Principle #9Preliminary anti-action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition achieves at least 80% prevention of flea blood feeding, effectively reducing the incidence of flea allergy dermatitis and providing prolonged treatment efficacy lasting up to three months by exterminating existing fleas and preventing their reproduction.

Implementation Method 1

cyphenothrin is a member of a class of synthetic insecticides known as pyrethroids... Cyphenothrin and other pyrethroids are axonic poisons that work by keeping the sodium channels open in the neuronal membranes

Methodology Applied

Scientific EffectContact toxicity of pyrethroid insecticide:

Implementation Method 2

Cyphenothrin and other pyrethroids are axonic poisons that work by keeping the sodium channels open in the neuronal membranes. This results in hyperexcitation, and the pest becomes paralyzed

Methodology Applied

Scientific EffectAxonic poison mechanism:

Implementation Method 3

The compositions for use of the present invention provide therefore for the inhibition of blood biting by fleas through the topical administration of compositions which repel fleas from taking a blood meal

Methodology Applied

Scientific EffectTopical delivery through organic solvent:

Data Source

PatentEP2861075B1Methods for preventing flea allergy dermatitis in companion animals

Publication Date: 2023.04.05 SERGEANT'S PET CARE PRODUCTS INC

AI summary

Methods for reducing the incidence of flea allergy dermatitis (FAD) in a companion animal are disclosed, the methods directed to inhibiting blood feeding by ectoparasites on a companion animal. The methods of the present invention involve administering a pesticide composition comprising cyphenothrin to a companion animal, specifically dogs and cats, in doses and proportions which are parasiticidally effective against a variety of ectoparasites, and in formulations which are convenient for topical application to the animal's skin, preferably localized over a small surface area. Such methods are useful in preventing and/or reducing the incidence of flea allergy dermatitis.