Motorized Stage Control for Cytological Specimen Scanning

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Solution Overview

Problem

Existing automated scanning systems for cytological specimens lack user control and flexibility, restricting the ability to pause, change scan directions, or review previously scanned portions, leading to limited control and convenience during specimen examination.

Innovation Solution

A system with a motorized stage, processor, and scan controller allows manual control of movement along scan lines, enabling users to controllably scan cytological specimens, index between scan lines, and pause or resume scanning as needed, using coaxial rotary control elements to manage stage movement and indexing.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If automated scanning systems are used to scan cytological specimens, then scanning coverage can achieve 100%, but user control and flexibility are lost

Engineering Contradiction:
Improvescanning coverageVSAvoiduser control
Core Design Contradiction:
Manufacturing precisionVSEase of operation

Solution Approach 1:

The system dynamically switches between fully automated scanning mode and manual control mode, allowing the degree of automation to be adjusted based on operational needs. The motorized stage can operate under programmatic control for systematic coverage or be manually positioned when user intervention is required, making the system adaptable rather than statically automated.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

A control interface acts as an intermediary between the user and the motorized stage, providing buttons and controls that enable manual positioning while maintaining the option for automated operation. This intermediary layer preserves user control without eliminating automated scanning capabilities.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Productivity

If automated scanning proceeds continuously without pauses, then scanning speed is maintained, but ability to review previously scanned portions is lost

Engineering Contradiction:
Improvescanning speedVSAvoidreview capability
Core Design Contradiction:
ProductivityVSAdaptability or versatility

Solution Approach 1:

The scanning process incorporates periodic pauses where the stage can be manually repositioned to review previously scanned areas. This interrupts the continuous automated scanning flow at intervals, allowing cytologists to examine regions of interest without completing the entire scan sequence, thereby combining systematic coverage with flexible review capability.

Inventive Principle:
Principle #19Periodic action

Solution Approach 2:

The system allows users to independently control the stage positioning and scanning pausing without requiring system reconfiguration. The cytologist can autonomously decide when to pause automated scanning and manually review specific areas, giving the user self-service control over the scanning process.

Inventive Principle:
Principle #25Self-service

3Ease of operation

If manual control of stage movement is provided, then user flexibility is enhanced, but scanning time increases

Engineering Contradiction:
Improveuser flexibilityVSAvoidscanning time
Core Design Contradiction:
Ease of operationVSLoss of time

Solution Approach 1:

Instead of requiring complete manual control for the entire scanning process, the system implements partial manual action only when needed for review or adjustment. The majority of the scanning can proceed automatically at high speed, with manual intervention applied selectively to specific portions of the specimen that require closer examination, thereby minimizing the time penalty associated with manual control.

Inventive Principle:
Principle #16Partial or excessive action

4Measurement precision

If motorized stage with multiple control elements is used, then control precision is improved, but device complexity increases

Engineering Contradiction:
Improvecontrol precisionVSAvoidcontrol element quantity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The control interface is designed with multi-functional buttons that perform different operations depending on the scanning state and context. A single control element can serve multiple purposes such as pausing scanning, enabling manual mode, and repositioning the stage, thereby reducing the total number of control elements needed while maintaining comprehensive control capability.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentEP2232320B1System for controlably scanning a cytological specimen
Publication Date: 2012.09.26 CYTYC CORP
  • EP2232320B1 patent drawingFigure 1A
  • EP2232320B1 patent drawingFigure 1B~2
  • EP2232320B1 patent drawingFigure 3

AI summary

A system for scanning a cytological specimen carried by a slide, wherein movement or positioning of a motorized stage of an automated screening system may be controlled manually by a user such that the user controls movement, e.g., controlling speed, position, and/or timing, of the motorized stage along a first scan line to controllably scan a first portion of the specimen along the scan line. The user may then index the motorized stage from the first scan line to the next scan line and manually control movement of the stage along the second scan line to controllably scan another portion of the specimen. Stage indexing may also be automatic such that the user does not control or initiate indexing.