Cytometer Unit Dual Fixing Devices Automated Alignment
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Solution Overview
Problem
The measurement accuracy of cytometric tests is sensitive to the precise orientation of the optical path relative to the cytometer channel, which is often complicated by non-uniform cross-sections and requires manual adjustments.
Innovation Solution
A cytometer unit with first and second fixing means that allow for automated orientation of the sample carrier, using mechanical, electrical, or magnetic interactions to position the cytometer channel transversely and along the optical path, enabling a two-step method for precise alignment without user intervention.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If manual adjustment is used to orient the cytometer channel, then precise alignment can be achieved, but the operation becomes complicated and time-consuming
Solution Approach 1:
The sample carrier is pre-equipped with orientation markers and geometric features (such as radial cytometer channels and specific coupling site configurations) that enable automatic alignment. The fixing means are pre-configured with bearing points and form-fit engagement features that automatically orient the sample carrier correctly when inserted, eliminating the need for manual adjustment during operation.
Solution Approach 2:
The system enables self-alignment through the interaction between the sample carrier's geometric features and the fixing means. The form-fit engagement and bearing points work together to automatically orient the cytometer channel along the optical path without requiring user intervention, making the system self-servicing in terms of alignment.
2Ease of operation
If automated orientation is implemented, then ease of operation improves, but device complexity increases due to additional fixing means
Solution Approach 1:
The automated orientation system is divided into two independent functional components: a first fixing means that contacts the sample carrier on one side to define position in a first adjustment direction, and a second fixing means that contacts the sample carrier to define position in a second adjustment direction. This segmentation allows each fixing means to be relatively simple while collectively achieving automated orientation.
Solution Approach 2:
The fixing means are designed to perform multiple functions: they not only secure the sample carrier in the receptacle but also simultaneously provide automated orientation in two different directions. The bearing points and form-fit engagement features serve both positioning and orienting functions, reducing the need for separate adjustment mechanisms.
3Measurement precision
If the optical path has non-uniform cross section, then measurement accuracy is improved by focusing, but the difficulty of detecting and measuring increases
Solution Approach 1:
The sample carrier is designed with asymmetric geometric features, including radial cytometer channels and specific orientation marker configurations, that create a unique geometric signature. This asymmetry ensures that when the sample carrier is engaged with the fixing means, there is only one correct orientation position that aligns the cytometer channel with the optical path, making detection and measurement straightforward.
Data Source
AI summary
In a cytometer unit (1) with a receptacle (2) into which a rotatable and preferably disk-shaped sample carrier (3) is insertable, it is proposed to define a first fixing means (14) for the definition of a position of a cytometer channel (12) of the inserted sample carrier (3) transversely with respect to the direction of extent thereof and transversely with respect to an optical path (11), by which a cytometric measurement can be carried out, and to use a second fixing means (19) to define a position of the cytometer channel (12) of the inserted sample carrier (3) along the optical path (11).