D-arabitol lipid-lowering hepatoprotection
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Solution Overview
Problem
Current treatments lack effective solutions for lipid-lowering and hepatoprotection, particularly in addressing high blood or liver lipid abnormalities that lead to atherosclerosis and liver damage.
Innovation Solution
D-arabitol is used as an active ingredient in drugs, healthcare products, or foods for lipid-lowering and hepatoprotection, administered orally or injected into patients with high blood or liver lipid levels to reduce lipid levels and protect the liver.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional lipid-lowering treatments are used, then blood lipid levels can be reduced, but they lack effective hepatoprotection and may cause side effects
Solution Approach 1:
The patent changes the chemical parameter by using D-arabitol (a specific sugar alcohol) instead of conventional lipid-lowering drugs. This parameter change enables simultaneous achievement of lipid-lowering and hepatoprotective effects without the harmful side effects associated with conventional treatments, as demonstrated in the animal model where D-arabitol reduced liver lipid accumulation and protected against liver damage while lowering blood lipids
2Quantity of substance
If high-fat diet is administered to animal models, then lipid accumulation in liver and blood increases, but it causes liver damage and atherosclerosis
Solution Approach 1:
The patent converts the harmful effect of high-fat diet-induced lipid accumulation into a beneficial demonstration of D-arabitol's protective effect. By administering D-arabitol to animals on high-fat diet, the patent shows that it can reverse the harmful lipid accumulation and protect against liver damage and atherosclerosis, transforming the harmful high-fat diet condition into an opportunity to demonstrate therapeutic efficacy
Data Source
AI summary
A use of D-arabitol in lipid-lowering and hepatoprotection is provided. Blood or liver lipid abnormalities refer to abnormalities in a quantity and a quality of lipids in the blood or liver, and usually refer to the elevation of cholesterol and/or triglycerides (TGs). Blood and liver lipid abnormalities can lead to atherosclerosis, increase the morbidity and mortality rates of cardio-cerebrovascular diseases, and cause the liver damage. D-arabitol has an excellent lipid-lowering and hepatoprotective effect, and has a prospect of being developed into a drug or health care product or food for lipid-lowering and hepatoprotection.