D-aspartic Acid Antioxidant Composition for Skin Stability

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Solution Overview

Problem

Conventional antioxidant compositions, such as those using ascorbic acid and α-tocopherol, are not stable enough for routine use in cosmetic and pharmaceutical products, necessitating the development of a more stable and safe antioxidant solution.

Innovation Solution

D-aspartic acid, its esters, or salts are used as antioxidants in external skin preparations and food compositions to address skin conditions caused by reactive oxygen species, including fine wrinkles, dry skin, skin cancer, skin allergies, and photosensitive dermatosis, with D-aspartic acid demonstrating antioxidant effects at concentrations of 0.1 µM to 10 µM.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional antioxidants like ascorbic acid and α-tocopherol are used in cosmetic and pharmaceutical products, then antioxidant effect is achieved, but stability is insufficient

Engineering Contradiction:
ImprovestabilityVSAvoidoxidative damage to skin
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameter from conventional antioxidants (ascorbic acid, α-tocopherol) to D-aspartic acid, which has superior stability properties. This parameter substitution resolves the contradiction by maintaining antioxidant efficacy while achieving the required stability for routine product use.

Inventive Principle:
Principle #35Parameter changes

2Object-affected harmful factors

If D-aspartic acid is used as antioxidant in skin preparations, then oxidative damages are suppressed, but safety and stability must be ensured for routine use

Engineering Contradiction:
Improveoxidative damagesVSAvoidstability and safety
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent employs D-aspartic acid as a stable, safe antioxidant that can be used routinely in cosmetic and pharmaceutical products. The substance provides reliable antioxidant protection without the stability issues of conventional antioxidants, enabling its use in stable formulations for long-term product shelf life and routine application.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

D-aspartic acid effectively suppresses oxidative damages in human fibroblast cells and is effective against both hydroxyl and peroxyl radicals, providing a stable and safe solution for improving skin conditions and potentially treating cataracts.

Implementation Method 1

D-aspartic acid effectively suppresses oxidative damages in human fibroblast cells and is effective against both hydroxyl and peroxyl radicals

Methodology Applied
Scientific EffectAntioxidant effect: Oxidation

Data Source

PatentEP2484354B1Antioxidant composition
Publication Date: 2019.05.29 SHISEIDO CO LTD
  • EP2484354B1 patent drawingFigure 1~2
  • EP2484354B1 patent drawingFigure 3~4
  • EP2484354B1 patent drawingFigure 5

AI summary

Disclosed is a stable and safe antioxidant composition which can be used routinely. Specifically disclosed is an antioxidant composition which contains one or more compounds selected from the group consisting of D-aspartic acid, derivatives thereof and/or salts thereof. The composition may be used for the purpose of suppressing and/or improving skin conditions. The skin conditions may include but is not limited to fine wrinkles, rough skin, dry skin, skin cancers, skin allergies, inflammation of the skin and photosensitive dermatosis. The composition may be used for an external preparation for the skin, food and a pharmaceutical product for cataract.