D-aspartic Acid Composition for Collagen Production

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current compositions for promoting collagen production, such as retinoids, have side effects like photosensitization and inflammatory reactions, and are prone to decomposition due to photoreactivity, necessitating protection from light, which limits their effectiveness in addressing skin conditions like wrinkles and photoaging.

Innovation Solution

A composition comprising D-aspartic acid, D-alanine, derivatives, or salts thereof, which are administered topically or orally to promote collagen production without the photoreactivity issues of retinoids, thereby improving skin conditions like wrinkles and photoaging.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If retinoids are used to promote collagen production, then collagen production is improved, but side effects such as photosensitization and inflammatory reactions occur

Engineering Contradiction:
Improvecollagen productionVSAvoidside effects (photosensitization and inflammatory reactions)
Core Design Contradiction:
ProductivityVSObject-generated harmful factors

Solution Approach 1:

The patent replaces retinoids with D-aspartic acid and D-alanine, which are safer, more stable amino acids that do not cause photosensitization or inflammatory reactions. These compounds serve as effective alternatives that eliminate the harmful side effects while maintaining collagen-promoting benefits

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent changes the chemical parameters by substituting retinoid compounds with specific amino acids (D-aspartic acid and D-alanine). This parameter change transforms the active ingredient from a photoreactive compound to photostable compounds, thereby eliminating photosensitization issues while preserving collagen production promotion

Inventive Principle:
Principle #35Parameter changes

2Productivity

If retinoids are used to promote collagen production, then collagen production is improved, but photoreactivity causes decomposition under light exposure

Engineering Contradiction:
Improvecollagen productionVSAvoidphotostability
Core Design Contradiction:
ProductivityVSStability of the object's composition

Solution Approach 1:

The patent replaces photoreactive retinoids with photostable amino acids (D-aspartic acid and D-alanine). These amino acids are inherently stable under light exposure, eliminating the need for special light protection measures while maintaining effective collagen promotion

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent changes the photostability parameter by substituting retinoids with amino acids that have superior photostability. This parameter change ensures the composition remains stable under ordinary living conditions without requiring special storage precautions

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS8637572B2Composition for promoting collagen production
Publication Date: 2014.01.28 SHISEIDO CO LTD
  • US8637572B2 patent drawing
  • US8637572B2 patent drawing
  • US8637572B2 patent drawing

AI summary

Disclosed is a novel composition which has an effect on promoting production of collagen. The composition has high photostability and is free from side effects such as those of retinoids. Specifically disclosed is a composition for promoting collagen production which contains one or more compounds selected from the group consisting of D-aspartic acid, D-alanine, derivatives and/or salts thereof. The composition may be used for the purpose of suppressing and/or improving skin a condition. The skin condition may include but is not limited to photoaging and/or wrinkles. The composition may be used for an external preparation for the skin or food. The composition may be a composition for promoting type I collagen production.