D-glutamic acid for UV-induced skin damage prevention
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Solution Overview
Problem
Conventional prophylactic and therapeutic agents for ultraviolet irradiation-induced skin damage are not routinely usable, stable, or safe, and primarily offer symptomatic relief, lacking effective prevention and treatment options for UV-induced skin conditions and cataracts.
Innovation Solution
Administration of D-glutamic acid and its salts, which can be incorporated into cosmetic, pharmaceutical, or food compositions, to provide a stable and safe solution for preventing or treating ultraviolet irradiation-induced skin damage, including wrinkles and cataracts, by alleviating UV-induced cell damage in keratinocytes and fibroblasts.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional ultraviolet scattering agents or absorbers are used for preventing sunburn, then ultraviolet protection is achieved, but routine usability is reduced due to stability and safety issues
Solution Approach 1:
The invention changes the chemical parameter from conventional ultraviolet scattering agents (titanium oxide) or absorbers (ethyl hexyl p-methoxycinnamic acid) to D-glutamic acid, which provides both superior stability and safety profiles, enabling routine daily use without the limitations of previous agents
Solution Approach 2:
D-glutamic acid offers a cost-effective alternative to conventional UV protection agents, providing stable and safe protection that can be used routinely without the stability concerns that limit the use of other agents
2Reliability
If conventional therapeutic agents are used for ultraviolet irradiation-induced skin damage, then symptomatic relief is provided, but effective prevention and treatment of underlying damage is lacking
Solution Approach 1:
D-glutamic acid is applied before ultraviolet irradiation to prevent skin damage from occurring in the first place, rather than merely treating symptoms after damage has occurred. This preliminary protective action addresses the root cause by enhancing cellular resistance to UV-induced stress
Solution Approach 2:
D-glutamic acid acts as a biochemical intermediary that mediates between ultraviolet radiation and skin cells, protecting keratinocytes and fibroblasts from damage through its antioxidant and cytoprotective properties, thereby preventing both immediate and long-term damage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
D-glutamic acid effectively alleviates ultraviolet irradiation-induced cell damage in a concentration-dependent manner, offering a novel and stable solution for routine use in preventing or treating UV-induced skin conditions and cataracts, as demonstrated by its ability to increase fluorescent intensity and reduce cell damage in human keratinocyte and fibroblast cultures.
Implementation Method 1
an antioxidant which removes a free radical generated by the ultraviolet
Data Source
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AI summary
Disclosed are: a composition for alleviating ultraviolet irradiation-induced damage, which can be used on a daily based and is stable and safe; and a pharmaceutical preparation, a cosmetic and a food composition, each of which comprises the composition. The composition for alleviating ultraviolet irradiation-induced damage contains one or more compounds selected from the group consisting of D-glutamic acid, L-glutamic acid, D-proline, D-cystine, L-cystine, and derivatives and/or salts of the aforementioned compounds. The composition can be used as an external formulation for the skin, a cosmetic composition, an anti-wrinkle agent, a sunscreen agent, a pharmaceutical composition for treating and/or preventing skin diseases, a food composition, or a pharmaceutical composition for preventing or treating cataract.